NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
基本信息
- 批准号:3287379
- 负责人:
- 金额:$ 12.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-09-01 至 1990-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The overall objective of this proposal is the development of new synthetic
methodologies using highly reactive metal powders. Several new approaches
for the preparation of highly reactive metal powders have been developed in
our laboratories. These metal powders exhibit far superior reactivity
towards oxidative addition reactions than any described for these metals in
the literature. Using these metals, a wide variety of new reactions and
dramatic extensions of existing reactions are proposed. The metal to be
studied include Ni, Cd, Zn, U, Fe, Mg, and Cu. While this study will not
be directed towards the synthesis of any one natural product, it is
anticipated that the results of this study will be of great value to the
synthetic community. Requests from synthetic chemists from all over the
USA and the world are constantly coming to our laboratories regarding
preparation and use of highly reactive metals developed in our
laboratories. The new chemistry proposed in this grant request will
provide for several new significant synthetic approaches. The highly
reactive magnesium studies should yield valuable extensions of Grignard
chemistry. Moreover, the facile generation of a five-membered magnesium
metallocycle should prove to be of extensive value. New cyclization
reactions using nickel, copper, and magnesium are proposed which will
tolerate a wide range of functionality. The ability to generate
organocadmium reagents and organocopper reagents directly from alkyl and
aryl halides with most any functionality will dramatically increase the
utility of these very versatile reagents. A new exciting class of
metal-lithium alloys is proposed; one of these may be an entry into highly
reactive lithium. Highly reactive zinc is expected to allow the
preparation of substituted cyclopropanes in the Simmons-Smith reaction.
Also, the direct preparation of dialkyl zinc reagents with a wide variety
of functional groups present is most probable. Several new classes of zero
valent complexes of Ni and Fe are proposed. The preparation of several new
organoiron species are proposed and several cross-coupling reactions with
these reagents are suggested. The highly reactive uranium will be used to
carry out reductive coupling reactions as well as to generate new
organouranium species. The synthetic utility of these new organometallic
species will be examined. Finally, this study will provide insight into
the origin of high reactivity at a metal surface as well as mechanistic
considerations regarding oxidative addition reactions at a metal surface.
本提案的总体目标是开发新的合成材料
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('REUBEN D RIEKE', 18)}}的其他基金
NEW REAGENTS AND MATERIALS FROM HIGHLY REACTIVE METALS
来自高活性金属的新试剂和材料
- 批准号:
2187618 - 财政年份:1993
- 资助金额:
$ 12.13万 - 项目类别:
NEW REAGENTS AND MATERIALS FROM HIGHLY REACTIVE METALS
来自高活性金属的新试剂和材料
- 批准号:
2187619 - 财政年份:1993
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287380 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287381 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287382 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287374 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
2177767 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287376 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287378 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
NEW SYNTHETIC METHODS USING HIGHLY REACTIVE METALS
使用高活性金属的新合成方法
- 批准号:
3287377 - 财政年份:1985
- 资助金额:
$ 12.13万 - 项目类别:
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