ATTENUATION CORRECTION IN POSITRON EMISSION TOMOGRAPHY

正电子发射断层扫描中的衰减校正

• 批准号: 2283983
• 负责人: GERD MUEHLLEHNER
• 金额: $ 27万
• 依托单位: UGM LABORATORY, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2283983
• 关键词: biomedical equipment development; positron emission tomography

Attenuation correction in positron emission tomography (PET) is usually achieved using a transmission scan, which is typically performed with one or several rotating rod sources containing a positron emitter such as Ge- 68. Since good statistics is required in the transmission scan, the imaging time is typically 10 to 20 minutes and the activity in the rod sources is as high as the scanner countrate capability permits. We propose to perform the transmission scan with a singles gamma-ray emitter, namely Cs-137, which has an energy of 662 keV, i.e. somewhat higher so that energy discrimination can be used to separate its energy from that of a positron emitter. Since only the transmitted gamma-rays are used and the source is shielded towards the nearer detectors, higher countrates and therefore shorter transmission scan can be obtained. During the Phase I we have demonstrated that high quality transmission scans can be achieved in as little as 2 minutes. PROPOSED COMMERCIAL APPLICATION: The completed singles transmission apparatus using a Cs-137 source will become a valuable enhancement for the PENN-PET scanners manufactured by UGM Medical Systems, improving the ease of performing attenuation correction and reducing the total patient examination time. The technique is potentially applicable to all PET scanners.

正电子发射断层扫描 (PET) 中的衰减校正通常是 使用传输扫描来实现，这通常是用一个 或几个包含正电子发射器的旋转棒源，例如Ge- 68. 由于传输扫描需要良好的统计数据，因此 成像时间通常为 10 至 20 分钟，并且杆中的活动 源是扫描仪计数能力允许的最高水平。 我们建议使用单束伽马射线进行透射扫描 发射体，即Cs-137，其能量为662 keV，即有点 更高，以便可以使用能量歧视来分离其能量 来自正电子发射器。由于只有透射的伽马射线 使用并且源被屏蔽到更近的探测器，更高 计数，因此可以获得更短的传输扫描。期间 第一阶段我们已经证明高质量的传输扫描可以 只需 2 分钟即可实现。 拟议的商业应用：已完成的单打传输 使用 Cs-137 源的设备将成为对 UGM Medical Systems 制造的 PENN-PET 扫描仪提高了易用性 执行衰减校正并减少患者总数 考试时间。该技术可能适用于所有 PET 扫描仪。