WHOLE BODY PET SCANNER USING LGSO DETECTORS

拟议研究的总体目标是开发一种针对全身研究进行优化的PET扫描仪，该扫描仪可以在+常规PET扫描仪的时间内累积两倍的计数。使用BGO（锗酸铋）的PET扫描仪受到FGD（氟脱氧葡萄糖）的最大活性量的限制，FGD（氟脱氧葡萄糖）可以在不超过患者最大剂量的情况下注射，并且基本上所有BGO系统都以2-D模式（插入隔膜）用于全身扫描。使用NaI（Tl）的PET扫描仪具有必要的能量分辨率，以便允许无隔膜的全3D模式，但是由于有限的计数能力而受到可以注入的最大量的限制。LGSO是一种新开发的闪烁体，其具有类似于BGO的高阻止本领，但同时具有高光输出以及相对于BGO和NaI（Tl）的非常短的衰减时间，从而潜在地导致良好的能量分辨率和高计数能力。拟议的研究将克服目前的PET扫描仪的局限性，通过允许无隔，全三维操作的身体成像在高分辨率和高灵敏度。拟议的商业应用：拟议的研究将导致PET扫描仪的开发，这是上级现有的PET扫描仪的常规临床全身肿瘤调查使用FDG。此外，该仪器还将用于许多其他PET应用。UGM目前生产PET扫描仪，并将把这种扫描仪添加到其产品线中。

The overall goal of the proposed research is to develop a PET scanner optirnized for whole-body studies which can accumulate twice the number of counts in + the time of conventional PET scanners. PET scanners using BGO (BismuthGermanate) are limited by the maximum amount of activity of FGD (FluoroDeoxyglucose) which can be injected without exceeding the maximum dose to the patient and the fact that essentially all BGO systems are used in 2-D mode (septa inserted), for whole body scanning. PET scanners using NaI(Tl) have the necessary energy resolution in order to permit full 3-D mode without septa, but are limited by the maximum amount which can be injected due to the limited countrate capability. LGSO is a newly developed scintillator which has the high stopping power similar to BGO but at the same time has a high light output as well as a very short decay time relative to both BGO and NaI(Tl), thereby potentially resulting in both good energy resolution and high countrate capability. The proposed research will overcome the limitations of present PET scanners, by permitting septaless, full 3-D operation for body imaging at high countrates and with high sensitivity. PROPOSED COMMERCIAL APPLICATIONS: The proposed research will lead to the development of a PET scanner which is superior to existing PET scanners for routine clinical whole-body tumor surveys using FDG. In addition, the instrument will also be useful for many other PET applications. UGM currently manufactures PET scanners and will add this scanner to its product line.