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WHOLE BODY PET SCANNER USING LGSO DETECTORS

使用 LGSO 探测器的全身宠物扫描仪

基本信息

批准号：
2874328
负责人：
GERD MUEHLLEHNER
金额：
$ 9.39万
依托单位：
UGM MEDICAL SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-05-01 至 1999-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2874328
关键词：
bioimaging /biomedical imaging biomedical equipment development bismuth fluorescence gadolinium nuclear medicine photomultiplier positron emission tomography radiation detector rare earth element scintillation counter whole body radionuclide scanning

项目摘要

The overall goal of the proposed research is to develop a PET scanner optirnized for whole-body studies which can accumulate twice the number of counts in + the time of conventional PET scanners. PET scanners using BGO (BismuthGermanate) are limited by the maximum amount of activity of FGD (FluoroDeoxyglucose) which can be injected without exceeding the maximum dose to the patient and the fact that essentially all BGO systems are used in 2-D mode (septa inserted), for whole body scanning. PET scanners using NaI(Tl) have the necessary energy resolution in order to permit full 3-D mode without septa, but are limited by the maximum amount which can be injected due to the limited countrate capability. LGSO is a newly developed scintillator which has the high stopping power similar to BGO but at the same time has a high light output as well as a very short decay time relative to both BGO and NaI(Tl), thereby potentially resulting in both good energy resolution and high countrate capability. The proposed research will overcome the limitations of present PET scanners, by permitting septaless, full 3-D operation for body imaging at high countrates and with high sensitivity. PROPOSED COMMERCIAL APPLICATIONS: The proposed research will lead to the development of a PET scanner which is superior to existing PET scanners for routine clinical whole-body tumor surveys using FDG. In addition, the instrument will also be useful for many other PET applications. UGM currently manufactures PET scanners and will add this scanner to its product line.

本研究的总体目标是开发一种适合全身研究的PET扫描仪，其计数次数是传统PET扫描仪的两倍+时间。使用BGO（锗酸铋）的PET扫描仪受到FGD（氟脱氧葡萄糖）最大活度的限制，FGD可以在不超过患者最大剂量的情况下注射，而且基本上所有BGO系统都是在二维模式（插入间隔）下使用，用于全身扫描。使用NaI（Tl）的PET扫描仪具有必要的能量分辨率，以便允许没有分隔的全3d模式，但由于有限的国家能力，可以注入的最大数量受到限制。LGSO是一种新开发的闪烁体，它具有与BGO相似的高停止能力，但同时具有高光输出和相对于BGO和NaI（Tl）非常短的衰减时间，从而具有良好的能量分辨率和高国家能力。拟议的研究将克服目前PET扫描仪的局限性，通过允许在高国家和高灵敏度的情况下进行身体成像的无间隔、全三维操作。拟议的商业应用：拟议的研究将导致PET扫描仪的开发，该扫描仪优于现有的PET扫描仪，用于FDG常规临床全身肿瘤调查。此外，该仪器也将用于许多其他PET应用。UGM目前生产PET扫描仪，并将把这种扫描仪添加到其产品线中。