IMAGE HANDLING SYSTEM FOR PATHOLOGY AND TELEPATHOLOGY

病理学和远程病理学图像处理系统

• 批准号: 2182513
• 负责人: KENDALL PRESTON
• 金额: $ 24.23万
• 依托单位: KENSAL CORPORATION
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-12 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2182513
• 关键词: cellular pathology; computer system design /evaluation; digital imaging; fiber optic microscopy; human tissue; image processing; online computer; personal computers; telecommunications; television; video microscopy

Surgical pathology is, approximately, a 20 billion dollar a year industry (USA only). Unlike cyto- and hemapathology that focus on microscopic cells, surgical pathology is concerned with large tissue sections. Tissue sections are mounted under a coverslip on standard 3x1 inch microscope slides of which from 50 to 100 million are prepared per year. For at least ten years the PI (Principal Investigator) has worked with surgical pathologists interested in digital image handling. Again and again they have emphasized the diagnostic importance of scanning tissue sections at the lowest magnification possible. Yet, physical optics absolutely prevents any microscope lens from imaging the entire 50X25 mm coverslip. To solve this problem, the PI invented and received a patent on (1988) an entirely new instrument called PCM (PC Microscope) that, using a semiconductor-diode, fiber-optic device would permit a FCS (full coverslip) scan employing "shadow imaging." In addition, PCM would provide real-time, high-magnification display of regions selected from the shadow image with submicron resolution. Phase I NIH SBIR funding was requested to study the feasibility of PCM. When FCS images were shown to surgical pathologists, the comments were "fantastic" [University of Southern California], "remarkable and magnificent" [Mayo Clinic], etc. The president of the Association of Pathology Chairmen, i.e., the top pathologists in the USA, stated that he envisaged a market of 50,000 units. In diametric opposition to these comments by our potential customers and for reasons that the PI finds incomprehensible, the two NIH Study Sections that reviewed our request for Phase II SBIR funding stated that PCM was only a "laboratory curiosity" with a "very limited, perhaps non-existent [market]." The PI, therefore, is again requesting Phase II SBIR funding to reduce PCM to practice and then use two or more PCMs in a network demonstration (telepathology) where FCS is essential. PROPOSED COMMERCIAL APPLICATION: Optical microscopy is used by thousands of surgical pathologists in the USA and further thousands worldwide. No microscope today can provide simultaneous images of the entire coverslip as well as high resolution images of selected portions thereof. KSC's new microscope system provides both fast full coverslip imaging as well as real-time HDTV in a single low-cost unit. KSC's system is seen as the next generation microscope for surgical pathology. The chairman of the largest pathology department in the USA estimates a market of 50,000 units.

外科病理学是一个每年大约200亿美元的行业。 (仅限美国)。与细胞病理学和血液病理学不同的是，细胞病理学和血液病理学侧重于微观 细胞，外科病理学与大的组织切片有关。组织 切片安装在标准3x1英寸显微镜的盖片下 每年准备5000万到1亿张幻灯片。至少在 PI(首席调查员)在外科工作了十年 对数字图像处理感兴趣的病理学家。他们一次又一次地 强调了扫描组织切片在诊断方面的重要性 可能的最低放大倍数。然而，物理光学绝对 防止任何显微镜镜头对整个50x25 mm进行成像 封面纸条。为了解决这个问题，PI发明并获得了一项关于 (1988)一种名为PCM(PC显微镜)的全新仪器， 使用半导体二极管、光纤设备将允许FCS(Full 封面)使用“阴影成像”的扫描。此外，PCM将 提供实时、高倍率显示从 具有亚微米分辨率的阴影图像。NIH SBIR第一阶段资金是 要求研究PCM的可行性。当显示FCS图像时 对于外科病理学家来说，这些评论是“奇妙的”。 南加州]、“非凡而宏伟”[梅奥诊所]等。 病理学主席协会主席，即最高层 美国的病理学家说，他设想了一个有5万人的市场 单位。与这些评论截然相反的是我们的潜力 客户以及PI认为难以理解的原因，这两个 NIH研究部分，审查了我们对第二阶段SBIR资金的申请 他说，PCM只是一个“实验室珍品”，“非常有限， 也许不存在[市场]。因此，PI再次要求 第二阶段SBIR资金用于将PCM减少到实践，然后使用两个或 FCS所在的网络演示(远程病理学)中的更多PCM 必不可少的。 建议的商业应用： 光学显微镜被数以千计的外科病理学家用于 美国和世界各地的数千人。今天没有显微镜可以提供 整个封面页的同时图像以及高分辨率 其选定部分的图像。KSC的新显微镜系统 同时提供快速全覆盖幻灯片成像和实时高清电视 单一的低成本单元。KSC的系统被视为下一代 外科病理学显微镜。最大的病理学学会会长 美国农业部估计市场销量为50,000台。