NEW GENERATION PATHOLOGISTS' MICROSCOPE

本建议书已提交给NIGMS，与明示的 该机构对显微仪器技术感兴趣 与生物物理学下的工程和物理科学有关 和生理科学项目。提交组织为 Kensal Consulting是亚利桑那州图森市的一家小型光电公司， 它发明了被认为是下一代的东西并为其申请了专利 病理学家的显微镜。这台新显微镜将带来全彩色 将组织切片数字化可视化到桌面上，并提供 病理学家用“PC显微镜”很可能会取代 传统显微镜。传统显微镜不能提供 全覆盖滑动成像；它也不提供方位信息；也不 它可以用来连续变焦吗？Kensal的PC显微镜，使用 新颖的线阵二极管幻灯片扫描仪，将带来全彩色、全彩色 在插入后1秒或2秒内将封面图片放到计算机屏幕上 显微镜滑入仪器。此后，用户将选择 通过指向封面幻灯片图像从屏幕获得感兴趣的区域 用一个光标。这些区域将以高倍率显示，并且可以 使用新型CFM连续平移、聚焦和缩放 (连续聚焦显微镜)最近获得Infinity Photo专利- 光学公司。不需要目镜，不需要手动操作 幻灯片和舞台；不需要手动切换固定功率目标，如 传统显微镜。本提案的目的是请求SBIR 为证明快速全覆盖滑动成像的可行性提供资金 为了研究这种成像方式与完整的、 将实施的数字控制的电光机构 作为第二阶段的PC显微镜原型，并在第二阶段商业化 三.

This proposal is submitted to NIGMS in connection with the expressed interest of that institution in microscopic instrumentation techniques related to the engineering and physical sciences under the Biophysics and Physiological Sciences Program. The submitting organization is Kensal Consulting, a small electrooptical business in Tucson, Arizona, that has invented and patented what is felt to be the next generation pathologists' microscope. This new microscope will bring full-color digital visualization of tissue sections to the desktop and provide the pathologist with a "PC-Microscope" that is likely to supplant traditional microscopy. The traditional microscope does not furnish full-coverslip imaging; nor does it provide orientation information; nor can it be used to continuously zoom. Kensal's PC-Microscope, using a novel linear-diode-array slide scanner, will bring a full-color, full- coverslip image to the computer screen 1 or 2 seconds after insertion of the microscope slide in the instrument. Thereafter the user will select regions of interest from the screen by pointing at the coverslip image with a cursor. These regions will appear at high magnification and can be panned, focused, and zoomed continuously using a novel CFM (Continuously Focusing Microscope) recently patented by Infinity Photo- Optical Company. No oculars will be necessary, no manual handling of the slide and stage; no manual switching of fixed-power objectives as in traditional microscopy. The purpose of this proposal is to request SBIR funding to demonstrate the feasibility of fast full-coverslip imaging and to study the combination of this imaging modality with a complete, digitally-controlled, electrooptical mechanism that will be implemented as a PC-Microscope prototype in Phase II and commercialized during Phase III.