NEW GENERATION PATHOLOGISTS' MICROSCOPE

新一代病理学家显微镜

• 批准号: 3498486
• 负责人: KENDALL PRESTON
• 金额: $ 5万
• 依托单位: KENSAL CORPORATION
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-12 至 1992-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498486
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; digital imaging; fiber optics; histopathology; microscopy; optics; personal computers; sectioning

This proposal is submitted to NIGMS in connection with the expressed interest of that institution in microscopic instrumentation techniques related to the engineering and physical sciences under the Biophysics and Physiological Sciences Program. The submitting organization is Kensal Consulting, a small electrooptical business in Tucson, Arizona, that has invented and patented what is felt to be the next generation pathologists' microscope. This new microscope will bring full-color digital visualization of tissue sections to the desktop and provide the pathologist with a "PC-Microscope" that is likely to supplant traditional microscopy. The traditional microscope does not furnish full-coverslip imaging; nor does it provide orientation information; nor can it be used to continuously zoom. Kensal's PC-Microscope, using a novel linear-diode-array slide scanner, will bring a full-color, full- coverslip image to the computer screen 1 or 2 seconds after insertion of the microscope slide in the instrument. Thereafter the user will select regions of interest from the screen by pointing at the coverslip image with a cursor. These regions will appear at high magnification and can be panned, focused, and zoomed continuously using a novel CFM (Continuously Focusing Microscope) recently patented by Infinity Photo- Optical Company. No oculars will be necessary, no manual handling of the slide and stage; no manual switching of fixed-power objectives as in traditional microscopy. The purpose of this proposal is to request SBIR funding to demonstrate the feasibility of fast full-coverslip imaging and to study the combination of this imaging modality with a complete, digitally-controlled, electrooptical mechanism that will be implemented as a PC-Microscope prototype in Phase II and commercialized during Phase III.

这一建议是向NIGMS提交的， 该机构对显微仪器技术的兴趣 与生物物理学下的工程和物理科学有关 生理科学计划。 提交组织是 肯萨尔咨询公司是亚利桑那州图森市的一家小型光电公司， 他们发明并申请了专利， 病理学家的显微镜 这台新显微镜将带来全彩色 将组织切片的数字化可视化传输到桌面， 病理学家与“电脑显微镜”，这是可能取代 传统显微镜 传统的显微镜不提供 全盖玻片成像;也不提供方向信息;也 它可以用来连续变焦。 Kensal的PC显微镜，使用 新的线性二极管阵列幻灯片扫描仪，将带来一个全彩色，全， 插入后1或2秒， 仪器中的显微镜载玻片。 之后，用户将选择 通过指向盖玻片图像， 一个游标。 这些区域将在高放大率下出现， 使用新颖的CFM连续进行平移、聚焦和缩放 （连续聚焦显微镜）最近由Infinity Photo获得专利- 光学公司 没有望远镜将是必要的，没有手动处理 幻灯片和阶段;没有手动切换固定功率物镜，如在 传统显微镜 本提案的目的是要求SBIR 资助证明快速全盖玻片成像的可行性 并研究这种成像方式与完整的， 数字控制的电光机制， 作为PC-显微镜原型在第II阶段，并在第II阶段商业化 三.