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ASYMPTOMATIC CAROTID ARTERY STENOSIS

无症状颈动脉狭窄

基本信息

批准号：
2264566
负责人：
JAMES F TOOLE
金额：
$ 233.57万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-09-09 至 1998-07-31
项目状态：
已结题

项目摘要

This proposal is for a continuation of a prospective, multicenter randomized clinical trial of medical/surgical therapy to prevent TIA and stroke in asymptomatic patients with stenosis of the common carotid bulb and/or internal carotid sinus -- the site of more than 90% of hemodynamically significant carotid artery atherosclerosis. The major aim of the study is to determine whether the addition of carotid endarterectomy to aspirin (325 mg) + best medical management will reduce the incidence of TIA and cerebral infarction in asymptomatic patients with hemodynamically significant carotid stenosis. Secondary objectives are to determine: (1) the surgical success in lesion removal and incidence of recurrent carotid stenosis following carotid endarterectomy, (2) the rate of progression (or regression) of carotid atherosclerosis in the medically treated group and in the control carotid arterial system, and (3) the incidence of coronary artery events (angina pectoris, non-fatal and fatal myocardial infarction) during follow-up. Quality assurance is a major component in study design. The results of the North American Symptomatic Carotid Endarterectomy Trial have demonstrated that carotid endarterectomy is the treatment of choice for symptomatic carotid artery stenosis exceeding 70%. It is estimated that the symptomatic subset represents only 10% of the prevalence of carotid stenosis. Therefore, it is all the more urgent to determine whether similar results apply to asymptomatic patients.

该提案旨在延续一项前瞻性、多中心的研究预防 TIA 的药物/手术治疗的随机临床试验颈总动脉球部狭窄的无症状患者中风和/或颈内动脉窦——超过 90% 的部位血流动力学显着的颈动脉粥样硬化。主要目标该研究的目的是确定是否加用颈动脉内膜切除术阿司匹林（325 毫克）+ 最佳医疗管理将减少以下疾病的发生无症状血流动力学患者TIA与脑梗死的关系颈动脉明显狭窄。次要目标是确定：(1) 病灶切除手术的成功率和颈动脉复发的发生率颈动脉内膜切除术后狭窄，(2) 进展率（或药物治疗组颈动脉粥样硬化的消退在控制颈动脉系统中，以及（3）冠状动脉疾病的发生率动脉事件（心绞痛、非致命性和致命性心肌梗死）随访期间。质量保证是研究设计的重要组成部分。北美症状性颈动脉内膜切除术试验结果已证明颈动脉内膜切除术是首选治疗方法适用于有症状的颈动脉狭窄超过70%。估计症状子集仅占患病率的 10% 颈动脉狭窄。因此，确定类似的结果是否适用于无症状患者。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comparison of centralized versus "site-based" measurement of angiographic stenosis for eligibility in the asymptomatic carotid atherosclerosis study.

无症状颈动脉粥样硬化研究中血管造影狭窄的集中测量与“基于部位”测量的比较。

DOI：
10.1097/00004424-199607000-00007
发表时间：
1996
期刊：
Investigative radiology
影响因子：
6.7
作者：
Dean,BL;Lefkowitz,DS;Howard,VJ;Frey,JF;Schwartz,S;Chambless,LE;Heiserman,JE;Feinberg,WM;Toole,JF
通讯作者：
Toole,JF

Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.

动脉内膜切除术治疗无症状颈动脉狭窄。