BEHAVIOR, BIOLOGICAL RHYTHMS AND BRAIN

描述：P.I.建议继续和扩展他的研究 昼夜节律视觉系统，即效应的神经解剖学基础 昼夜节律的光。该提案有三个总体目标： 首先是理解5-羟色胺能系统作为调节器的作用。 昼夜节律性的。这一系列研究将结合 电刺激和药理学技术评估(A) 上升的5-羟色胺能系统对昼夜节律的控制，(B) 光对昼夜节律相位反应的抑制控制 上升的5-羟色胺能系统和(C)阐明 中缝背核或中缝正中核参与昼夜节律 监管。 二是对这一关系的阐释 5-羟色胺能系统与Fos蛋白的光传导之间的关系 SCN或膝间小叶(IGL)细胞。实验将是 评估(A)5-羟色胺系统激活的能力 阻断Fos蛋白在SCN或IGL神经元的诱导，以及(B)是否 是控制5-羟色胺能神经元的中缝背核或中缝正中核 SCN和IGL中的活动。 第三组实验将调查 丘脑后限核是丘脑核团的“新”部分。 昼夜节律视觉系统。这里的假设源于观察。 IGL与PLI在解剖上是相连的，并继续 IGL传出和传入解剖学的研究也在计划之中。私家侦探 将研究(A)IGL与PLI的关系，(B) 视网膜传入PLI，(C)传入/传入关系 IGL和上丘；(D)昼夜节律功能 我的朋友们。

DESCRIPTION: P.I. proposes to continue and extend his studies of the circadian visual system, i.e. neuroanatomical substrate of the effects of light of circadian rhythms. The proposal has three general aims: The first is to understand the role serotonergic system as a modulator of circadian rhythmicity. This series of studies will combine electrical stimulation and pharmacological techniques to evaluate (a) circadian phase control by the ascending serotonergic system, (b) inhibitory control of the circadian rhythms phase response to light by the ascending serotonergic system and (c) elucidation of whether the dorsal or median raphe nuclei are involved in circadian rhythm regulation. The second is directed towards the elucidation of the relationship between serotonergic system and the photoconduction of FOS-protein by SCN or intergeniculate leaflet (IGL) cells. Experiments will be conducted which evaluate (a) the ability of serotonin system activation to block FOS protein induction in SCN or IGL neurons and (b) whether it is the dorsal or median raphe nucleus that controls the serotonergic activity in the SCN and IGL. The third group of experiments will investigate the possibility that the PLi - the posterior limitans thalamic nucleus is a "new" part of the circadian visual system. The hypothesis here arises out of observations that the IGL is anatomical connected with the PLi, and continued investigations of IGL efferent and afferent anatomy are planned. P.I. will study (a) the IGL's relationship to the PLi, (b) the sites of retina input to the PLi, (c) the efferent/afferent relationship between the IGL and superior colliculus, and (d) the circadian rhythm function of the PLi.