BEHAVIOR, BIOLOGICAL RHYTHMS AND BRAIN
行为、生物节律和大脑
基本信息
- 批准号:2668966
- 负责人:
- 金额:$ 20.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-04-01 至 1999-03-31
- 项目状态:已结题
- 来源:
- 关键词:brain mapping circadian rhythms dorsal raphe nucleus electrostimulus experimental brain lesion fos protein hamsters immunocytochemistry neural information processing neuroanatomy photoactivation photostimulus serotonin superior colliculus suprachiasmatic nucleus thalamic nuclei visual pathways visual phototransduction
项目摘要
DESCRIPTION: P.I. proposes to continue and extend his studies of the
circadian visual system, i.e. neuroanatomical substrate of the effects
of light of circadian rhythms. The proposal has three general aims:
The first is to understand the role serotonergic system as a modulator
of circadian rhythmicity. This series of studies will combine
electrical stimulation and pharmacological techniques to evaluate (a)
circadian phase control by the ascending serotonergic system, (b)
inhibitory control of the circadian rhythms phase response to light by
the ascending serotonergic system and (c) elucidation of whether the
dorsal or median raphe nuclei are involved in circadian rhythm
regulation.
The second is directed towards the elucidation of the relationship
between serotonergic system and the photoconduction of FOS-protein by
SCN or intergeniculate leaflet (IGL) cells. Experiments will be
conducted which evaluate (a) the ability of serotonin system activation
to block FOS protein induction in SCN or IGL neurons and (b) whether it
is the dorsal or median raphe nucleus that controls the serotonergic
activity in the SCN and IGL.
The third group of experiments will investigate the possibility that the
PLi - the posterior limitans thalamic nucleus is a "new" part of the
circadian visual system. The hypothesis here arises out of observations
that the IGL is anatomical connected with the PLi, and continued
investigations of IGL efferent and afferent anatomy are planned. P.I.
will study (a) the IGL's relationship to the PLi, (b) the sites of
retina input to the PLi, (c) the efferent/afferent relationship between
the IGL and superior colliculus, and (d) the circadian rhythm function
of the PLi.
描述:P.I.建议继续和扩展他的研究
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAWRENCE P MORIN其他文献
LAWRENCE P MORIN的其他文献
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{{ truncateString('LAWRENCE P MORIN', 18)}}的其他基金
Support for a Workshop on Circuits of the Circadian System
支持昼夜节律系统回路研讨会
- 批准号:
8005841 - 财政年份:2010
- 资助金额:
$ 20.28万 - 项目类别:
Regulation of Masking and Circadian Rhythm Phase
掩蔽和昼夜节律阶段的调节
- 批准号:
8055553 - 财政年份:2009
- 资助金额:
$ 20.28万 - 项目类别:
Regulation of Masking and Circadian Rhythm Phase
掩蔽和昼夜节律阶段的调节
- 批准号:
7715075 - 财政年份:2009
- 资助金额:
$ 20.28万 - 项目类别:
Regulation of Masking and Circadian Rhythm Phase
掩蔽和昼夜节律阶段的调节
- 批准号:
8245115 - 财政年份:2009
- 资助金额:
$ 20.28万 - 项目类别:
Regulation of Masking and Circadian Rhythm Phase
掩蔽和昼夜节律阶段的调节
- 批准号:
7812104 - 财政年份:2009
- 资助金额:
$ 20.28万 - 项目类别:
Regulation of Masking and Circadian Rhythm Phase
掩蔽和昼夜节律阶段的调节
- 批准号:
7869561 - 财政年份:2009
- 资助金额:
$ 20.28万 - 项目类别:
Regulation of Masking and Circadian Rhythm Phase
掩蔽和昼夜节律阶段的调节
- 批准号:
7873138 - 财政年份:2009
- 资助金额:
$ 20.28万 - 项目类别:
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