LEXICAL DECISION-MAKING IN PARKINSON'S DISEASE

帕金森病的词汇决策

• 批准号: 2268588
• 负责人: Gregory G Brown
• 金额: $ 4.35万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2268588
• 关键词: Parkinson's disease; antiparkinson drugs; cognition disorders; computer program /software; decision making; dementia; dihydroxyphenylalanine; dopamine agonists; expectancy; human subject; intelligence tests; memory; neural information processing; neuropharmacology; neuropsychological tests; neuropsychology; performance; psychomotor reaction time; semantics; stimulus /response; visual perception; vocabulary

The general aim of this study is to gain a better understanding of a phenomena that we have observed in a large minority (about 40%) of non-demented patients with Parkinson's disease. The phenomena involves PD patients showing a greater degree of semantic facilitation (priming) than controls on a version of the lexical decision task used in our laboratory. Our general strategy in studying this phenomena will be to determine whether this counterintuitive effect can be related to any of the other cognitive and motor abnormalities present in non-demented PD patients. Three potential explanations for increased semantic priming in PD will be considered: the motor slowing facilitation hypotheses, the degraded semantic knowledge hypothesis, and the impaired decision making hypothesis. The first experiment will seek to determine whether motor slowing and reduced recognition vocabulary contribute to semantic facilitation on a word pronunciation task, where postlexical decision making processes contribute little to performance. This experiment will compare the performance of Parkinson patients on and off anti-Parkinsonian medication. The second experiment will manipulate the type of prime (associative vs categorical) and the base rates for words appearing on the lexical decision task in order to influence the decision making strategy of subjects. The third experiment will attempt to determine whether increased semantic priming is greatest for words about which subjects have degraded semantic knowledge. This study will attempt to replicate previous work in Alzheimer's disease and extend the results to demented and nondemented patients with Parkinsonism. Furthermore, this study will aim to determine whether the breakdown of semantic knowledge, when it is observed in dementing conditions, involves specific words or specific case relations. Data from this study may help clarify inconsistent findings in the literature about lexical decision making in Parkinsonism. They may also establish the importance of the neglected decision making stage of lexical decision performance and help with the interpretation of lexical decision results obtained in other aphasic and degenerative conditions. These experiments may contribute to the development of a neuropharmacologic theory of cognitive functioning in Parkinsonism and may identify a subgroup of nondemented Parkinson patients at risk for cognitive dysfunction.

本研究的总体目的是为了更好地了解 我们在少数人（约40%）中观察到的现象 非痴呆的帕金森病患者 这些现象涉及到 PD患者表现出更大程度的语义易化（启动） 比对照组中使用的词汇判断任务的一个版本， 实验室 我们研究这种现象的一般策略是， 确定这种违反直觉的影响是否与以下任何因素有关： 非痴呆性PD中存在的其他认知和运动异常 患者 三种可能的解释增加语义启动 PD将被考虑：运动减慢促进假说， 退化的语义知识假设，以及受损的决策 假说. 第一个实验将试图确定是否电机 减缓和减少识别词汇有助于语义 促进一个词的发音任务，其中词汇后的决定， 使得工艺对性能贡献很小。 这个实验将 比较帕金森病人在治疗和不治疗时的表现 抗帕金森病药物 第二个实验将操纵 素数的类型（联想与分类）和单词的基本比率 出现在词汇决定任务中，以影响决定 制定学科战略。 第三个实验将尝试 确定增加的语义启动是否对关于 哪些受试者的语义知识退化了。 本研究将尝试 复制之前在阿尔茨海默病方面的工作， 帕金森症的痴呆和非痴呆患者。 此外，委员会认为， 本研究的目的是确定语义的崩溃是否 知识，当它被观察到在痴呆的条件下，涉及具体的 词或特定的情况下的关系。 这项研究的数据可能有助于澄清 关于词汇决策的文献中存在不一致的发现， 帕金森症。 他们也可以建立被忽视的重要性 决策阶段的词汇决策性能和帮助 解释在其他失语症和 退化的条件。 这些实验可能有助于 发展认知功能的神经药理学理论， 帕金森综合征，并可能确定一个亚组的非痴呆性帕金森 有认知功能障碍风险的患者。