Neuroimaging (NI) Core

神经成像（NI）核心 鉴于艾滋病毒感染（HIV+）和甲基苯丙胺使用（METH+）对大脑结构的不良影响， 和功能，它们的综合作用，无论是加和还是协同作用，预计将产生一个 严重的脑部疾病此外，由于艾滋病毒感染的治疗延长了寿命， METH使用者年龄队列，与衰老和衰老合并症相关的大脑变化可能 导致HIV+和METH+相关的大脑结构和功能改变。特别是与年龄有关的 脑血管病可改变脑血流，增强白色改变， 物质体积衰老也可能加剧预期由白色物质引起的大脑连通性的变化 与HIV+和METH+相关的变化。是否老化有助于大脑结构的变化 和功能是加性的或协同的预期从艾滋病毒感染或甲基使用是未知的。这 核心建议使用平移多模态成像，以支持调查的程度， 衰老介导与HIV感染、甲基苯丙胺依赖及其 互动为了支持这些调查，NI核心资源目标是：（1）提供TMARC 研究人员与一组核心的人类和小鼠成像数据;（2）提供专门的成像协议 和先进的图像分析工具，以支持新兴成像技术的新方向;以及（3） 培训研究人员成像方法。N1核心科学目标是：（1）研究单独的 和关节脑异常的患者的神经心理和功能障碍， HIV感染和METH使用及其与衰老的相互作用;（2）使用多模式成像方法将 在METH使用和HIV感染中观察到的白色物质变化， 大脑中心;（3）使用与人类研究中使用的磁共振成像方案相当的磁共振成像方案， 将人类成像结果与HIV感染和甲基苯丙胺小鼠模型的成像结果联系起来 使用.

NEUROIMAGING(Nl)CORE Given the adverse effects of HIV infection (HIV+) and methamphetamine use (METH+) oh brain structure and function, their combined effects, whether additive or synergistic, would be expected to produce a significant brain disorder. Moreover, as treatment of HIV infection has improved longevity and as the large cohort of METH users age, brain changes related to aging and to the comorbidities of aging are likely to contribute to HIV+ and METH+ related alterations in brain structure and function. In particular, age-related cerebrovascular disease might alter cerebral blood flow, potentiate white matter changes and alter gray matter volume. Aging is also likely to exacerbate changes in brain connectivity expected from white matter changes associated with HIV+ and METH+. Whether the aging contribution to changes of brain structure and function is additive or synergistic to that expected from HIV infection or METH use are unknown. This Core proposes to use translational multi-modal imaging to support investigations into the extent to which aging mediates brain changes associated with HIV infection, methamphetamine dependence and their interaction. To support these investigations the Nl Core Resource Objectives are to: (1) provide TMARC investigators with a core set of human and mouse imaging data; (2) provide specialized imaging protocols and advanced image analysis tools to support new directions in emerging imaging technologies; and (3) train investigators in imaging methods. The Nl Core Scientific Objectives are to: (1) investigate the separate and joint brain abnormalities underlying the neuropsychological and functional disabilities of patients with HIV infection and METH use and their interaction with aging; (2) use multimodal imaging methods to link white matter changes seen in METH use and HIV infection to alterations of functional connections among brain centers; (3) use magnetic resonance imaging protocols comparable to those used in human studies to link human imaging findings to imaging findings in mouse models of HIV infection and methamphetamine use.