SPECTROSCOPY OF ALZHEIMER'S DISEASE & VASCULAR DEMENTIA
阿尔茨海默病的光谱学
基本信息
- 批准号:3122617
- 负责人:
- 金额:$ 20.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-09-29 至 1996-06-30
- 项目状态:已结题
- 来源:
- 关键词:Alzheimer's disease aspartate brain disorder diagnosis brain metabolism clinical biomedical equipment dementia diagnosis quality /standard energy source frontal lobe /cortex human subject neuropsychological tests neuropsychology nuclear magnetic resonance spectroscopy phosphates phosphorus radionuclide imaging /scanning radionuclides
项目摘要
The overall aim of this project is to determine, using 31-Phosphorous (31P)
and proton (1H) nuclear magnetic resonance (NMR) spectroscopy, if brain
metabolic markers exist that will distinguish Alzheimer's disease from
dementia associated with multiple sites of subcortical ischemia. A five
year longitudinal study will investigate clinical, imaging (magnetic
resonance imaging, MRI), metabolic (in vivo 31P and 1H NMR) and
neuropathologic data in selected patients with multiple subcortical
ischemic dementia (MSID), Alzheimer's disease (AD), or mixed AD and
vascular disease. and in nondemented elderly controls. The study aims to
characterize changes in brain energy phosphate, phospholipid metabolism,
pH, free magnesium, N-acetyl aspartate, and cholinated compounds that might
accurately predict clinical and pathologic diagnoses of AD, MSID, and mixed
MSID/AD. Further, two hypotheses will be tested to explain the shift
towards the high energy phosphate end of the phosphorus spectrum previously
reported in MSID. One hypothesis attributes the shift to a decreased
utilization of molecular energy in superficial brain regions disconnected
from neuronal input by subcortical lesions. The other hypothesis attributes
the shift to increased astrocytic reactivity in cortical regions that have
been subjected to mild levels of ischemia. The first hypothesis predicts
that the extent of the high energy phosphate shift should be correlated
with the extent and location of the subcortical white matter
hyperintensities observed on MRI. The second hypothesis predicts that MSID
patients with a shift towards the high energy phosphate end of the
phosphorus spectrum will have microcavities and increased glial
immunoreactivity in cortical regions where spectra are obtained, even
though these areas appeared to be normal on MRI.
该项目的总体目标是使用31-磷(31 P)
和质子(1H)核磁共振(NMR)光谱,如果大脑
代谢标志物的存在,将区分阿尔茨海默病,
与多部位皮质下缺血相关的痴呆。 五
一年的纵向研究将调查临床,成像(磁
共振成像,MRI)、代谢(体内31 P和1H NMR)和
选择的多发性皮质下神经病变患者的神经病理学数据
缺血性痴呆(MSID)、阿尔茨海默病(AD)或混合AD,以及
血管疾病和非痴呆老年对照组。该研究旨在
表征脑能量磷酸盐,磷脂代谢,
pH值、游离镁、N-乙酰天冬氨酸和可能
准确预测AD、MSID和混合型AD的临床和病理诊断
MSID/AD。 此外,两个假设将进行测试,以解释转变
朝向磷光谱的高能磷酸盐端,
在MSID中报告。 一种假设将这种转变归因于
在断开的大脑表层区域中利用分子能量
来自皮层下损伤的神经元输入。其他假设属性
皮质区域星形胶质细胞反应性增加的转变,
受到了轻微的局部缺血 第一个假设预测
高能磷酸盐迁移的程度应该与
皮质下白色物质的范围和位置
MRI上观察到高信号。 第二个假设预测MSID
向高能磷酸盐端转移的患者,
磷光谱将有微腔和增加的胶质细胞
在获得光谱的皮质区域中的免疫反应性,甚至
尽管这些区域在核磁共振成像上看起来很正常
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregory G Brown其他文献
Gregory G Brown的其他文献
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{{ truncateString('Gregory G Brown', 18)}}的其他基金
MRI Assessment of Hippocampal Volume and Function in a Mouse Model of PTSD
PTSD 小鼠模型海马体积和功能的 MRI 评估
- 批准号:
8513417 - 财政年份:2012
- 资助金额:
$ 20.84万 - 项目类别:
MRI Assessment of Hippocampal Volume and Function in a Mouse Model of PTSD
PTSD 小鼠模型海马体积和功能的 MRI 评估
- 批准号:
8354886 - 财政年份:2012
- 资助金额:
$ 20.84万 - 项目类别:
SPECTROSCOPY OF ALZHEIMERS DISEASE & VASCULAR DEMENTIA
阿尔茨海默病的光谱学
- 批准号:
2051923 - 财政年份:1991
- 资助金额:
$ 20.84万 - 项目类别:
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