Sexual conflict and evolutionary dynamics of insecticide resistance genes

性别冲突与杀虫剂抗性基因的进化动态

• 批准号: FL190100134
• 负责人: Prof Nina Wedell
• 金额: $ 215.34万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL190100134
• 关键词: Sexual; conflict; evolutionary; dynamics; insecticide

This project aims to develop new approaches to mitigate resistance evolution by applying sexual selection theory to predict evolution of insecticide resistance in flies. A key assumption of current agriculture management strategies is that resistance carries fecundity or survival costs, but this is rarely demonstrated, especially in nature. Not all resistance mutations are novel; many represent pre-existing variants maintained by balancing selection i.e. opposing effects in males and females, or by environmental fluctuations. This research will provide new insight into how resistance evolves and is maintained in natural populations and may result in potential reduction in pesticide use with associated economic and biodiversity benefits.

本项目旨在通过应用性选择理论来预测苍蝇对杀虫剂的抗性进化，从而开发新的方法来减缓抗性进化。当前农业管理战略的一个关键假设是，抗性会带来繁殖力或生存成本，但这很少得到证明，特别是在自然界。并非所有耐药突变都是新的;许多代表通过平衡选择（即男性和女性中的相反效应）或环境波动维持的预先存在的变体。这项研究将提供新的见解，以了解抗性如何演变和维持在自然种群中，并可能导致潜在的减少农药使用与相关的经济和生物多样性效益。