SEX HORMONES AND POSTMENOPAUSAL SLEEP CHANGES

多达四分之三的绝经后女性抱怨说， 零碎的睡眠。然而，很少有研究调查 与年龄相关的性激素变化之间的假定关系 侧写和睡眠障碍。性激素水平显示出年龄- 相关变化，并继续在世界各地发挥重要作用 寿命。随着年龄的增长，尤其是在更年期， 雌激素(E2)和睾酮(T)显著下降，而 黄体生成素和卵泡刺激素 水平显著增加；这些变化随着 年龄越来越大。主要从围绝经期获得的证据 表明这些荷尔蒙的变化与睡眠有关 骚乱。同样，也有数量有限的研究聚焦于 激素替代治疗对绝经后妇女的影响 表明雌激素对睡眠障碍有保护作用， 而较高的促黄体生成素水平可能会导致体温调节或其他 与睡眠质量差有关的变化。这是一次对 假设夜间雌二醇和睾酮水平与促黄体生成素和黄体生成素的平衡 FSH是睡眠障碍的预测因素是睡眠障碍的主要焦点 目前的建议。 具体地说，这项研究将调查 三组女性的性激素水平和睡眠障碍。 年轻(20-30岁)绝经前妇女，老年(60岁以上) 绝经后妇女和年龄较大(60岁以上)的绝经后妇女 雌激素替代疗法(ERT)将花费一次适应和两次 在睡眠实验室里度过基线之夜。多导睡眠图睡眠和 每晚都会评估身体核心温度，并经常进行血浆检查 第三天晚上将采集雌二醇、睾酮、黄体生成素和卵泡刺激素。它是 预测雌二醇和/或睾酮与促黄体生成素和/或促卵泡刺激素的比率将会更高 在青年组和老年组的ERT上观察到 这两组人的睡眠效率会显著提高 睡眠不那么零碎。 这项研究被视为建立一个 研究性激素和睡眠的研究项目 寿命以及与年龄相关的睡眠变化相关的过程 男人和女人。

Up to three-quarters of postmenopausal women complain of disturbed, fragmented sleep. Yet, remarkably few studies have investigated putative relationships between age-associated changes in sex hormone profiles and sleep disturbance. Sex hormone levels exhibit age- related changes, and continue to play a significant role across the lifespan. With aging, and specifically at menopause, levels of estrogen (E2) and testosterone (T) decrease significantly, while luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels increase significantly; these changes are exacerbated with increasing age. Evidence, obtained primarily from perimenopausal women, suggests that these hormonal changes are associated with sleep disturbance. Likewise, a limited number of studies focusing on the effects of hormone replacement therapy on postmenopausal women indicate that E2 plays a protective role against sleep disturbance, while higher levels of LH may induce thermoregulatory or other changes that are associated with poor sleep quality. A test of the hypothesis that the balance of nighttime levels of E2 and T to LH and FSH is predictive of sleep disturbance is the primary focus of the current proposal. Specifically, this study will investigate the relationship between sex hormone levels and sleep disturbance in three groups of women. Young (20-30 years) premenopausal women, older (60+ years) postmenopausal women, and older (60+ years) postmenopausal women on estrogen replacement therapy (ERT) will spend an adaptation and two baseline nights in a sleep laboratory. Polysomnographical sleep and body core temperature will be assessed each night and frequent plasma sampling of E2, T, LH, and FSH will occur on the third night. It is predicted that a higher ratio of E2 and/or T to LH and/or FSH will be observed in the young group and the older group on ERT, and that these two groups will exhibit significantly higher sleep efficiency and less fragmented sleep. This study is viewed as the necessary first step to establishing a program of research investigating sex hormones and sleep across the lifespan, and processes involved in age-related sleep changes in both men and women.