SEX HORMONES SLEEP AND CIRCADIAN RHYTHMICITY IN AGING
性激素、睡眠和衰老过程中的昼夜节律
基本信息
- 批准号:6372179
- 负责人:
- 金额:$ 20.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-01 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Changes in the processes controlling sleep that accompany aging result
in widespread complaints of sleep disturbance in otherwise healthy older
individuals. It is likely that age-related changes in many
physiological systems interact to produce these sleep problems. One
such system is the hypothalamic-pituitary-gonadal (HPG) axis. Gonadal
steroids exhibit significant declines with age, resulting in altered
negative feedback to the hypothalamus, and unregulated production of
luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Recent
evidence demonstrates that these alterations continue and worsen with
increasing age.
That changing levels of gonadal hormones affect sleep quality in aging
is supported by both anecdotal and empirical evidence. For example, up
to two-thirds of perimenopausal women complain of sleep problems.
Further, higher LH levels are associated with awakenings from sleep, and
hormone replacement therapy improves objectively-measured sleep.
Although investigations of sex hormones and sleep in men are rare, lower
levels of testosterone in aging men have been associated with poorer
sleep quality. Indeed, the few studies that have assessed sleep
complaints in the context of age-associated changes in HPG functioning
strongly suggest that further investigation is needed. In addition,
while changes in the circadian timing system are widely believed to
contribute to sleep problems in older individuals, little is known about
whether circadian patterns of sex hormone release are modified as a
function of aging.
The proposed research plan combines a chronobiological approach to the
study of changes in the HPG axis in aging with an investigation of
whether sex hormone levels are associated with age-related sleep
problems. One study will assess whether there are circadian rhythms in
sex hormones independent of sleep, and whether patterns of gonadal
hormone release are altered with aging. The second study will examine
whether the balance of sex steroids and gonadotropins differs between
older individuals without sleep complaints and those with sleep
maintenance insomnia. The combination of findings from these studies
will clarify our understanding of how sex hormones, sleep, and circadian
rhythmicity interact in aging, providing an avenue for investigating
hormone replacement therapies as treatments for sleep problems in older
individuals.
伴随着衰老导致的睡眠控制过程的变化
在对其他健康老年人睡眠障碍的普遍抱怨中
个人。很可能许多与年龄相关的变化
生理系统的相互作用会产生这些睡眠问题。一
这样的系统就是下丘脑-垂体-性腺(HPG)轴。性腺
类固醇随着年龄的增长而显著下降,导致
对下丘脑的负反馈,以及不受调节的产生
黄体生成素(LH)和卵泡刺激素(FSH)。近期
有证据表明,随着时间的推移,这些变化会继续并恶化。
年龄越来越大。
性腺激素水平的变化会影响衰老过程中的睡眠质量
得到了轶事和经验证据的支持。例如,UP
到三分之二的围绝经期妇女抱怨睡眠问题。
此外,较高的促黄体生成素水平与从睡眠中醒来有关,并且
激素替代疗法改善了客观测量的睡眠。
尽管对男性性激素和睡眠的研究很少,但
老年男性的睾丸素水平与较贫穷有关
睡眠质量。事实上,为数不多的几项评估睡眠的研究
HPG功能随年龄变化而引起的投诉
强烈建议需要进一步调查。此外,
虽然人们普遍认为昼夜节律系统的变化
导致老年人睡眠问题的原因,目前知之甚少
性激素释放的昼夜节律模式是否被修改为
衰老功能。
拟议的研究计划结合了时间生物学方法来研究
HPG轴在衰老过程中变化的研究
性激素水平是否与年龄相关的睡眠有关
有问题。一项研究将评估是否存在昼夜节律
性激素独立于睡眠,以及性腺的模式
荷尔蒙的释放会随着年龄的增长而改变。第二项研究将检查
性激素和促性腺激素的平衡是否不同于
没有睡眠问题的老年人和有睡眠问题的老年人
维持性失眠。这些研究的结果结合在一起
将澄清我们对性激素、睡眠和昼夜节律
节律性在衰老中的相互作用,为研究提供了一条途径
激素替代疗法治疗老年人睡眠问题
个人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PATRICIA J MURPHY其他文献
PATRICIA J MURPHY的其他文献
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{{ truncateString('PATRICIA J MURPHY', 18)}}的其他基金
Sleep Activity Patterns and Temperature in Childhood Onset Bipolar Disorder
儿童期发作的双相情感障碍的睡眠活动模式和温度
- 批准号:
7682194 - 财政年份:2008
- 资助金额:
$ 20.68万 - 项目类别:
Sleep Activity Patterns and Temperature in Childhood Onset Bipolar Disorder
儿童期发作的双相情感障碍的睡眠活动模式和温度
- 批准号:
7535887 - 财政年份:2008
- 资助金额:
$ 20.68万 - 项目类别:
MELATONIN FOR AGE-RELATED SLEEP DISTURBANCE IN WOMEN
褪黑激素治疗女性年龄相关睡眠障碍
- 批准号:
6988861 - 财政年份:1998
- 资助金额:
$ 20.68万 - 项目类别:
SEX HORMONES SLEEP AND CIRCADIAN RHYTHMICITY IN AGING
性激素、睡眠和衰老过程中的昼夜节律
- 批准号:
6169088 - 财政年份:1998
- 资助金额:
$ 20.68万 - 项目类别:
MELATONIN FOR AGE-RELATED SLEEP DISTURBANCE IN WOMEN
褪黑激素治疗女性年龄相关睡眠障碍
- 批准号:
7117386 - 财政年份:1998
- 资助金额:
$ 20.68万 - 项目类别:
SEX HORMONES SLEEP AND CIRCADIAN RHYTHMICITY IN AGING
性激素、睡眠和衰老过程中的昼夜节律
- 批准号:
6055472 - 财政年份:1998
- 资助金额:
$ 20.68万 - 项目类别:
SEX HORMONES SLEEP AND CIRCADIAN RHYTHMICITY IN AGING
性激素、睡眠和衰老过程中的昼夜节律
- 批准号:
2594467 - 财政年份:1998
- 资助金额:
$ 20.68万 - 项目类别:
SEX HORMONES SLEEP AND CIRCADIAN RHYTHMICITY IN AGING
性激素、睡眠和衰老过程中的昼夜节律
- 批准号:
6533786 - 财政年份:1998
- 资助金额:
$ 20.68万 - 项目类别:
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