MORTALITY IN WORKERS WITH INTERMITTENT ASBESTOS EXPOSURE

间歇性接触石棉工人的死亡率

• 批准号: 2039495
• 负责人: STEPHEN R ZOLOTH
• 金额: $ 19.25万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2039495
• 关键词: X ray; asbestos; disease /disorder proneness /risk; human data; human mortality; human subject; lung; lung neoplasms; occupational health /safety; respiratory function; smoking

The harmful effects of asbestos exposure have been identified in numerous cohorts involved in the mining and fabrication of asbestos products. This proposal requests funds for a cohort and nested ease-control analysis of mortality among Sheet Metal Workers, members of the building trades with significant, intermittent asbestos exposure. Although several studies have described the effect of asbestos exposure on health of construction workers, the majority have been cross-sectional screening programs or analyses of proportionate mortality. These studies demonstrate the presence of asbestos related disease, but due to methodological limitations do not quantify levels of risk: The majority of data available on the risk of asbestos disease in construction comes from studies of insulators. However, insulators, faced exposures far higher than the majority of the building trades. Investigation of mortality in Sheet Metal Workers provides the opportunity to directly measure the risk of asbestos related disease in a cohort with intermittent asbestos exposure, secondary to their work in construction. A further, unique advantage of the proposed study is the opportunity to combine the analysis of mortality with the findings of a screening program for asbestos related disease. In 1986, Sheet Metal Workers who were members of this cohort were invited to participate in a nationwide medical screening program. Data on work history, job tasks, current symptoms, smoking histories and the results of pulmonary function tests - and chest x-rays are available for 12,454 union members. The existence of these data allows the exploration of hypotheses relating health status at the time of medical screening with subsequent mortality. A nested case-control study within the screened cohort is also proposed to examine the important question of whether radiographic signs of asbestos exposure, pleural and parenchymal changes, predict lung cancer mortality. To increase the quality of the x-ray data, a panel of three "B" readers will re-read all x-rays. Finally, comparison of cause specific mortality between the population participating in the screening program (respondents) with those who did not (non-respondents), will allow examination of participation bias. This ability to explore participation bias is rare in occupational cohort studies.

暴露在石棉中的有害影响已被确认为许多 参与开采和制造石棉产品的人员。这 提案要求资金用于队列和嵌套的轻松控制分析 从事建筑行业的板金工人的死亡率 大量间歇性接触石棉。 尽管有几项研究描述了接触石棉的影响 在建筑工人的健康问题上，大多数人都是横截面的 比例死亡率的筛查计划或分析。这些研究 证明存在与石棉有关的疾病，但由于 方法上的限制并不能量化风险水平：大多数 关于建筑施工中石棉疾病风险的现有数据 来自绝缘体的研究。然而，绝缘子面临着远距离的暴露 比大多数建筑行业都要高。调查 金属板材工人的死亡率提供了直接 在队列中测量与石棉相关疾病的风险 间歇性石棉暴露，其次是他们在建筑方面的工作。 拟议研究的另一个独特优势是有机会 将死亡率分析与筛查结果结合起来 石棉相关疾病方案。1986年，金属板材工人 这个队列的成员是否被邀请参加一项全国性的 体检计划。关于工作历史、工作任务、当前的数据 症状，吸烟史和肺功能测试结果- 并为12,454名工会成员提供胸部X光检查。他的存在 这些数据允许探索与健康状况相关的假设 在医学筛查时，随后死亡。 还建议在筛选的队列中进行嵌套病例对照研究。 检查重要的问题，即是否有放射学征象 石棉暴露、胸膜和实质改变可预测肺癌 死亡率。为了提高x射线数据的质量，一个由三人组成的小组 B级读者将重新阅读所有的X光照片。 最后，比较两组人群的死因死亡率。 与参加筛查计划的人(受访者)一起参加 不是(非受访者)，将允许审查参与偏见。这 探索参与偏见的能力在职业队列中很少见 学习。