HOST TUMOR INTERACTION IN BURKITTS LYMPHOMA

SJL小鼠卵泡中心B细胞模型的研究进展 淋巴瘤(RCS)在转录和转录之间建立了很强的联系 一种新的内源性小鼠乳腺肿瘤病毒(MMTV) 间接癌基因，介导强大的超抗原样刺激 RCS生长所依赖的同基因的CD4+Vbeta16+T细胞。 RCS淋巴瘤与Burkitt淋巴瘤有许多共同的显著特征 (Bl)。这两种淋巴瘤都是生发中心起源的(都表现为 生发中心特异性抗原(CD77)；和RCS淋巴瘤一样，BL肿瘤 有T细胞渗入可能在 淋巴肿大。这项提议的总体目标是利用 RCS模型中的发现作为剖析宿主T的作用的基础 细胞在胚层发育中的作用。鉴于BL的异构性 肿瘤，我们将检查来自各种不同来源的一些非洲BL肿瘤 加纳(淋巴瘤流行的地方)的患者试图将肿瘤联系起来 表型对特定宿主T细胞亚群的刺激作用 以及它们对细胞凋亡的敏感性。

Our recent work on the SJL mouse model of follicular center B cell lymphoma (RCS) has established a strong link between the transcription of a novel endogenous mouse mammary tumor virus (MMTV) that serves as an indirect oncogen, mediating the vigorous superantigen-like stimulation of syngeneic CD4+Vbeta16+ T cells upon which RCS depend for their growth. RCS lymphomas share a number of salient features with Burkitt's lymphomas (BL). Both lymphomas are germinal center derived (both express the germinal center specific antigen, CD77); and like RCS lymphomas, BL tumors have T cell infiltrations that could have a potential role in the lymphomagenesis. The overall aim of this proposal is to utilize the findings in the RCS model as a basis for dissection of the role of host T cells in the development of BL. In view of the heterogeneous nature of BL tumors, we will examine a number of African BL tumors from various patients in Ghana (where BL is prevalent) in an attempt to relate tumor phenotypes to their stimulation of particular host T cell subpopulations and to their sensitivity to apoptosis.