LYMPHOID CELLS PRODUCTION OF ANTIBODIES

从淋巴组织中的生殖中心细胞的功能和命运将是 在小鼠和鸡中分析。 将特别注意 动力学事件及其与B记忆细胞功能变化的相关性。 放射性标记的致敏和未致敏B细胞的定位，以及 局部特异性抗原对分离致敏B细胞定位的影响 在接受者中，将在形态和功能上进行跟踪。 通过单独注射抗独特型或以抗独特型的形式注射抗独特型诱导B细胞记忆 将在A/J小鼠中尝试具有独特型的免疫复合物， 在该菌株中对ARS反应的主要独特型。 A/J无胸腺小鼠 背景也将包括在内。 如果获得了这种预充， 对应的将被研究相对于Germinant中心生成。 研究 对小鼠对TNP反应期间急性抗独特型形成的影响 多糖载体正在继续强调其在 免疫耐受诱导和独特型特异性T细胞在其中的作用 现象 TNF-α多糖阻断B细胞受体的实验研究 抗原正在进行，以分析这种可逆性， 在细胞的剩余反应性方面阻断程序。 的 水泡性口炎病毒感染对诱导 将分析与体内辅助T细胞相比的抑制T细胞。 最后，表皮朗格汉斯细胞正在研究和比较中 在功能上与淋巴组织的交错网状细胞有关。

The function and fate of germinal center cells from lymphoid tissues will be analyzed in both mice and chickens. Particular attention will be given to kinetic events and their correlation to functional changes in B memory cells. Localization of radioactively labeled primed and unprimed B cells, and the influence of localized specific antigen on isolated primed B cell localization in recipients, will be followed both morphologically and functionally. Induction of B cell memory by injection of anti-idiotype alone or in the form of immune complex with idiotype will be tried in A/J mice, using the model of the major idiotype in the response to ARS in this strain. Athymic mice of A/J background will also be included. If such priming is obtained, the histological counterpart will be studied with respect to germinal center generation. Studies on acute antiidiotype formation during the response of mice to TNP on polysaccharide carriers are being continued with emphasis on its role in tolerance induction and on the role of idiotype specific T cells in this phenomenon. Experiments on B cell receptor blockade with TNP-polysaccharide antigens are being conducted in order to analyze the reversibility of such blockade procedures in terms of remaining responsiveness of the cells. The influence of infection with vesicular stomatitis virus on the induction of suppressor T cells as compared to helper T cells in vivo will be analyzed. Finally, the epidermal Langerhans cell is being studied and compared functionally to interdigitating reticulum cells of lymphoid tissue.