MUSCLE MATRIX AND BLADDER FUNCTION

描述：（改编自申请人摘要）尿失禁 是一个问题，估计有1000万美国人的所有年龄，是一个 老年人机构化的主要原因。 膀胱出口 继发于良性前列腺肥大（BPH）的阻塞也是一个主要的 当一个人考虑到100亿美元， （保守估计为400，000例切除术）每年花费在 手术治疗疾病。 前列腺增生的主要症状是 继发于梗阻对膀胱平滑肌的影响。 的 据估计，这两个医疗问题每年给国家带来的费用为 200亿美元。 膀胱功能障碍的许多症状可能是 药物管理，但目前可用的药物是 过时的，不够有效的。 需要更多的基础科学 研究了解膀胱平滑肌如何在正常情况下发育 胎儿和新生儿时期，它如何随着年龄的变化（在男性和 女性），以及它对阻塞的反应。 建议的目的 会议是为了汇集膀胱光滑的主要研究小组 肌肉生理学交流思想和信息。 20人的场地 主要发言人（大部分在下尿路工作 生理学至少3年）将介绍他们的实验室的工作， 30分钟，然后是简短的讨论。 将有4个开放的45 分小组讨论。 目标是为每个主要发言人提供 一个论坛，详细讨论他们正在进行的工作， 来自其他小组成员和观众的建设性反馈。 一 展览将安排海报展示环节，吸引年青人或新来港定居人士参与 调查人员到现场。 所有参加的调查人员都将被邀请 将他们的工作贡献给一本将由Plenum出版的专著。 这次会议将是独一无二的，原因有几个：1）从来没有 这样一个深入的会议，专门讨论平滑肌的主题， 下尿路功能; 2）它将涵盖正常的变化 膀胱生理学，发生在胎儿开始，并通过正常 成长和成熟; 3）它将详细介绍目前的理解 出口梗阻对平滑肌功能的影响;以及4） 除了讨论平滑肌功能的细胞内基础之外， 这次会议还将集中在细胞外基质的作用， 以及它如何影响尿液的主动和被动特性 膀胱

DESCRIPTION: (Adapted from the applicant's abstract) Urinary incontinence is a problem for an estimated 10 million Americans of all ages, and is a leading cause for institutionalization of the elderly. Bladder outlet obstruction secondary to benign prostatic hypertrophy (BPH) is also a major medical issue facing the nation when one considers that 10 billion dollars (a conservative figure for 400,000 prostatectomies) is spent yearly on surgical management of the disease. The major symptoms of BPH are secondary to the effects of obstruction on bladder smooth muscle. The annual cost to the nation for these 2 medical problems is estimated to be 20 billion dollars. Many of these symptoms of bladder dysfunction could be managed medically, but the current pharmacologic agents available are outdated and not effective enough. There is a need for more basic science research to understand how bladder smooth muscle develops in the normal fetal and newborn period, how it changes with aging (in both males and females), and how it responds to obstruction. The purpose of the proposed conference is to bring together the major research groups in bladder smooth muscle physiology for an exchange of ideas and information. A field of 20 primary speakers (most of whom have been working in lower urinary tract physiology for at least 3 years) will present their laboratory's work for 30 minutes followed by a brief discussion period. There will be 4 open 45 minute panel discussions. The goal is to provide each primary speaker with a forum to discuss their ongoing work in detail, and receive in depth constructive feedback from their fellow panelists and the audience. A poster session will be arranged to attract work from young or new investigators to the field. All investigators who attend will be invited to contribute their work to a monograph which will be published by Plenum. The conference will be unique for several reasons: 1) there has never been such an in depth conference devoted solely to the topic of smooth muscle function of the lower urinary tract; 2) it will cover the changes in normal bladder physiology that occur beginning in the fetus and on through normal growth and maturation; 3) it will cover in detail the current understanding of the effects of outlet obstruction on smooth muscle function; and 4) in addition to discussing the intracellular basis for smooth muscle function, this conference will also focus in on the role of the extracellular matrix and how it may influence the active and passive properties of the urinary bladder.