MUSCLE MATRIX AND BLADDER FUNCTION

肌肉基质和膀胱功能

• 批准号: 2146673
• 负责人: Stephen Anthony Zderic
• 金额: $ 2万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2146673
• 关键词: extracellular matrix; meeting /conference /symposium; muscle function; smooth muscle; travel; urinary bladder

DESCRIPTION: (Adapted from the applicant's abstract) Urinary incontinence is a problem for an estimated 10 million Americans of all ages, and is a leading cause for institutionalization of the elderly. Bladder outlet obstruction secondary to benign prostatic hypertrophy (BPH) is also a major medical issue facing the nation when one considers that 10 billion dollars (a conservative figure for 400,000 prostatectomies) is spent yearly on surgical management of the disease. The major symptoms of BPH are secondary to the effects of obstruction on bladder smooth muscle. The annual cost to the nation for these 2 medical problems is estimated to be 20 billion dollars. Many of these symptoms of bladder dysfunction could be managed medically, but the current pharmacologic agents available are outdated and not effective enough. There is a need for more basic science research to understand how bladder smooth muscle develops in the normal fetal and newborn period, how it changes with aging (in both males and females), and how it responds to obstruction. The purpose of the proposed conference is to bring together the major research groups in bladder smooth muscle physiology for an exchange of ideas and information. A field of 20 primary speakers (most of whom have been working in lower urinary tract physiology for at least 3 years) will present their laboratory's work for 30 minutes followed by a brief discussion period. There will be 4 open 45 minute panel discussions. The goal is to provide each primary speaker with a forum to discuss their ongoing work in detail, and receive in depth constructive feedback from their fellow panelists and the audience. A poster session will be arranged to attract work from young or new investigators to the field. All investigators who attend will be invited to contribute their work to a monograph which will be published by Plenum. The conference will be unique for several reasons: 1) there has never been such an in depth conference devoted solely to the topic of smooth muscle function of the lower urinary tract; 2) it will cover the changes in normal bladder physiology that occur beginning in the fetus and on through normal growth and maturation; 3) it will cover in detail the current understanding of the effects of outlet obstruction on smooth muscle function; and 4) in addition to discussing the intracellular basis for smooth muscle function, this conference will also focus in on the role of the extracellular matrix and how it may influence the active and passive properties of the urinary bladder.

描述：（改编自申请人的摘要）尿失禁 对于大约1000万美国人来说，这是一个问题，并且是 老年人制度化的主要原因。 膀胱出口 继发于良性前列腺肥大（BPH）的阻塞也是主要的 当人们认为100亿美元时，国家面临的医疗问题 （一个保守的人物40万个前列腺切除术）每年花费 该疾病的手术管理。 BPH的主要症状是 继发于阻塞对膀胱平滑肌的影响。 这 据估计，这两个医疗问题的年度费用为 200亿美元。 膀胱功能障碍的许多症状可能是 在医疗上进行管理，但目前可用的药理剂 过时，不够有效。 需要更多的基础科学 研究以了解膀胱平滑肌在正常下如何发展 胎儿和新生时期，它如何随着衰老而变化（在男性和 女性），及其对阻塞的反应。 提议的目的 会议是将Bladder的主要研究小组汇集在一起 肌肉生理，以交换思想和信息。 20个领域 主扬声器（大多数人一直在尿道下工作 生理学至少3年）将展示其实验室的工作 30分钟，然后进行简短的讨论期。 将有4个公开45 小组讨论。 目的是为每个主要扬声器提供 一个论坛，讨论他们正在进行的工作，并深入讨论 他们的小组成员和观众的建设性反馈。 一个 海报会议将安排吸引年轻或新的工作 调查人员到该领域。 所有参加的调查人员将被邀请 为了将其作品贡献给将由Plenum出版的专着。 会议将是独一无二的，原因有几个：1）从来没有 这样的深度会议仅专门用于平滑肌主题 下尿路的功能； 2）它将涵盖正常的变化 膀胱生理从胎儿开始，直到正常 生长和成熟； 3）它将详细介绍当前的理解 出口阻塞对平滑肌功能的影响；和4）in 除了讨论平滑肌功能的细胞内基础， 这次会议还将重点关注细胞外基质的作用 以及如何影响尿液的主动和被动特性 膀胱。