MUSCLE MATRIX AND BLADDER FUNCTION

肌肉基质和膀胱功能

• 批准号: 2146673
• 负责人: Stephen Anthony Zderic
• 金额: $ 2万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2146673
• 关键词: extracellular matrix; meeting /conference /symposium; muscle function; smooth muscle; travel; urinary bladder

DESCRIPTION: (Adapted from the applicant's abstract) Urinary incontinence is a problem for an estimated 10 million Americans of all ages, and is a leading cause for institutionalization of the elderly. Bladder outlet obstruction secondary to benign prostatic hypertrophy (BPH) is also a major medical issue facing the nation when one considers that 10 billion dollars (a conservative figure for 400,000 prostatectomies) is spent yearly on surgical management of the disease. The major symptoms of BPH are secondary to the effects of obstruction on bladder smooth muscle. The annual cost to the nation for these 2 medical problems is estimated to be 20 billion dollars. Many of these symptoms of bladder dysfunction could be managed medically, but the current pharmacologic agents available are outdated and not effective enough. There is a need for more basic science research to understand how bladder smooth muscle develops in the normal fetal and newborn period, how it changes with aging (in both males and females), and how it responds to obstruction. The purpose of the proposed conference is to bring together the major research groups in bladder smooth muscle physiology for an exchange of ideas and information. A field of 20 primary speakers (most of whom have been working in lower urinary tract physiology for at least 3 years) will present their laboratory's work for 30 minutes followed by a brief discussion period. There will be 4 open 45 minute panel discussions. The goal is to provide each primary speaker with a forum to discuss their ongoing work in detail, and receive in depth constructive feedback from their fellow panelists and the audience. A poster session will be arranged to attract work from young or new investigators to the field. All investigators who attend will be invited to contribute their work to a monograph which will be published by Plenum. The conference will be unique for several reasons: 1) there has never been such an in depth conference devoted solely to the topic of smooth muscle function of the lower urinary tract; 2) it will cover the changes in normal bladder physiology that occur beginning in the fetus and on through normal growth and maturation; 3) it will cover in detail the current understanding of the effects of outlet obstruction on smooth muscle function; and 4) in addition to discussing the intracellular basis for smooth muscle function, this conference will also focus in on the role of the extracellular matrix and how it may influence the active and passive properties of the urinary bladder.

描述：（改编自申请人的摘要）尿失禁 估计有 1000 万各个年龄段的美国人都面临这个问题 将老年人送入机构的主要原因。 膀胱出口 良性前列腺肥大（BPH）继发的梗阻也是一个主要的原因。 当人们想到100亿美元时，国家面临的医疗问题 （400,000 例前列腺切除术的保守数字）每年花费在 该疾病的手术治疗。 前列腺增生症的主要症状是 继发于膀胱平滑肌阻塞的影响。 这 这两个医疗问题每年给国家造成的损失估计为 200亿美元。 膀胱功能障碍的许多症状可能是 医学上进行管理，但目前可用的药物有 已经过时且不够有效。 需要更多基础科学 研究了解膀胱平滑肌在正常情况下如何发育 胎儿期和新生儿期，它如何随着年龄的增长而变化（无论是男性还是新生儿） 女性），以及它如何应对阻塞。 拟议的目的 会议汇集了膀胱平滑方面的主要研究小组 肌肉生理学以交流思想和信息。 20个字段 主要发言人（其中大多数人一直在下尿路工作） 生理学至少 3 年）将展示他们实验室的工作 30 分钟，随后是简短的讨论时间。 将会有 4 开放 45 分钟小组讨论。 目标是为每位主要发言人提供 一个论坛，详细讨论他们正在进行的工作，并深入了解 来自小组成员和观众的建设性反馈。 一个 将安排海报会议以吸引年轻人或新人的作品 调查人员前往实地。 所有出席的调查人员都将被邀请 将他们的工作贡献给将由全体会议出版的专着。 本次会议之所以独一无二，有以下几个原因：1） 如此深入的会议专门讨论平滑肌的主题 下尿路功能； 2）它将覆盖正常的变化 膀胱生理学从胎儿开始发生并贯穿正常 成长和成熟； 3）它将详细介绍当前的理解 出口阻塞对平滑肌功能的影响；和 4) 在 除了讨论平滑肌功能的细胞内基础之外， 本次会议还将重点讨论细胞外基质的作用 以及它如何影响尿液的主动和被动特性 膀胱。