A novel approach to treating neuroinflammation

治疗神经炎症的新方法

• 批准号: 56191
• 金额: $ 43.7万
• 依托单位: MONUMENT THERAPEUTICS LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=56191
• 关键词: novel; approach; treating; neuroinflammation

Over recent years it has become clear that inflammation in the brain may be a key factor contributing to many psychiatric and neurological conditions such as Alzheimer's disease and depression. Unfortunately, standard anti-inflammatory drugs such as ibruprofen do not help, because the way they are formulated stops them from being able to get into the brain, which is surrounded by a special protective layer called the blood-brain barrier. We have accessed a new formulation of a widely-used anti-inflammatory drug which has been specifically designed to have increased brain penetration. In this project we will show that this formulation can reduce brain inflammation in mice, and that it can penetrate the blood-brain barrier in human cells. If successful, this evidence will justify trying the newly formulated drug in humans, with first studies expected to start in 2022\. These first human studies will be for people undergoing elective surgeries such as hip replacements, which tends to cause a short-term inflammation in the brain as well as other parts of the body. As part of this project, we will develop a digital tool that allows us to detect who is at highest risk of developing cognitive problems as a result of these types of surgery. This will be used to select patients for future studies of the drug, and also to help doctors and patients understand and prospectively treat the brain-related risks associated with elective surgeries.

近年来，已经很清楚，大脑中的炎症可能是导致许多精神和神经疾病的关键因素，如阿尔茨海默病和抑郁症。不幸的是，像伊布洛芬这样的标准抗炎药无济于事，因为它们的配方方式阻止了它们进入大脑，大脑周围有一层特殊的保护层，称为血脑屏障。我们获得了一种广泛使用的抗炎药物的新配方，这种药物是专门为增加大脑渗透率而设计的。在这个项目中，我们将展示这种制剂可以减少小鼠的脑部炎症，并且它可以穿透人类细胞的血脑屏障。如果成功，这一证据将证明在人体上尝试这种新配方的药物是合理的，第一批研究预计将于2022年开始。这些首批人体研究将用于接受髋关节置换等选择性手术的人，髋关节置换往往会导致大脑和身体其他部位的短期炎症。作为该项目的一部分，我们将开发一种数字工具，使我们能够检测谁因这些类型的手术而出现认知问题的风险最高。这将用于为该药物的未来研究选择患者，并帮助医生和患者了解和前瞻性地治疗与选择性手术相关的脑相关风险。