Synthesis of Polynuclear Aromatic Hydroca

多核芳烃的合成

• 批准号: 2551171
• 负责人: MARY J TANGA
• 金额: $ 28.51万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-25 至 2001-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2551171
• 关键词: Synthesis; Polynuclear; Aromatic; Hydroca

The objective of this contract is to synthesize highly purified, well- characterized compounds that may have utility in the biological processes involved in carcinogenesis. Some of the compounds bay be carcinogens e.g., nitrosamines such as the tobacco specific carcinogens NNN, NNK, or anabasine. Some may be metabolic intermediates e.g., benzo(a)pyrene~ 7,8 diol, which is an intermediate in the metabolic conversion of benzo(a)pyrene to the potent ultimate carcinogen benzo(a)pyrene 7, 8 diol 9,10 epoxide. Some compounds may have demonstrated high mutagenicity and have a known exposure to humans but carcinogenic data are lacking, e.g., fecapentaenes, heterocyclic amine food mutagens. Other compounds may serve as biomarkers of exposure such as PAH DNA or protein adducts.

本合同的目的是合成高纯度，良好- 可用于生物过程的特征化合物 参与了致癌作用。 有些化合物可能是致癌物质， 亚硝胺，如烟草特异性致癌物NNN、NNK，或 假木贼碱 有些可能是代谢中间体，苯并（a）芘~ 7，8 二醇，是代谢转化的中间体 苯并（a）芘到潜在的终极致癌物苯并（a）芘7，8二醇 9，10环氧化物一些化合物可能已证明具有高致突变性， 已知暴露于人类，但缺乏致癌数据，例如， fecapentaenes，杂环胺食品诱变剂。 其他化合物可用于 作为暴露的生物标志物，如PAH DNA或蛋白质加合物。