Synthesis of Polynuclear Aromatic Hydroca

这份合同的目标是合成高度纯化的，良好的- 可能在生物过程中有用的具有特征的化合物 与癌症的发生有关。有些化合物是致癌物质，例如， 亚硝胺，如烟草特有的致癌物NNN、NNK或 阿纳巴辛。有些可能是代谢中间体，例如苯并(A)芘~7，8 二醇，这是代谢转化的中间产物 从苯并(A)芘到强致癌物质苯并(A)芘7，8二醇 9，10环氧化物。一些化合物可能表现出高度的致突变性和 已知与人类接触，但缺乏致癌数据，例如， 杂环胺类食品致突变剂。其他化合物可能会起作用 作为暴露的生物标志物，如多环芳烃DNA或蛋白质加合物。

The objective of this contract is to synthesize highly purified, well- characterized compounds that may have utility in the biological processes involved in carcinogenesis. Some of the compounds bay be carcinogens e.g., nitrosamines such as the tobacco specific carcinogens NNN, NNK, or anabasine. Some may be metabolic intermediates e.g., benzo(a)pyrene~ 7,8 diol, which is an intermediate in the metabolic conversion of benzo(a)pyrene to the potent ultimate carcinogen benzo(a)pyrene 7, 8 diol 9,10 epoxide. Some compounds may have demonstrated high mutagenicity and have a known exposure to humans but carcinogenic data are lacking, e.g., fecapentaenes, heterocyclic amine food mutagens. Other compounds may serve as biomarkers of exposure such as PAH DNA or protein adducts.