Synthesis of Polynuclear Aromatic Hydroca

多核芳烃的合成

• 批准号: 2651052
• 负责人: MARY J TANGA
• 金额: $ 28.68万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-25 至 2001-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651052
• 关键词: benzopyrenes; biomarker; carbopolycyclic compound; chemical addition; chemical carcinogen; chemical carcinogenesis; chemical synthesis; mutagens; nitrosamines

The objective of this contract is to synthesize highly purified, well- characterized compounds that may have utility in the biological processes involved in carcinogenesis. Some of the compounds bay be carcinogens e.g., nitrosamines such as the tobacco specific carcinogens NNN, NNK, or anabasine. Some may be metabolic intermediates e.g., benzo(a)pyrene~ 7,8 diol, which is an intermediate in the metabolic conversion of benzo(a)pyrene to the potent ultimate carcinogen benzo(a)pyrene 7, 8 diol 9,10 epoxide. Some compounds may have demonstrated high mutagenicity and have a known exposure to humans but carcinogenic data are lacking, e.g., fecapentaenes, heterocyclic amine food mutagens. Other compounds may serve as biomarkers of exposure such as PAH DNA or protein adducts.

该合同的目标是合成高度纯化、良好的 可能在生物过程中有用的特征化合物 参与致癌作用。 有些化合物可能是致癌物，例如， 亚硝胺，例如烟草特有致癌物 NNN、NNK 或 假木香。 有些可能是代谢中间体，例如苯并(a)芘~ 7,8 二醇，是代谢转化的中间体 苯并(a)芘转变为强效最终致癌物苯并(a)芘7、8二醇 9,10环氧化物。一些化合物可能表现出高致突变性 已知与人类接触，但缺乏致癌数据，例如 fecapentaenes，杂环胺食品诱变剂。 其他化合物也可发挥作用 作为暴露的生物标志物，例如 PAH DNA 或蛋白质加合物。