MECHANISMS OF CHEMICAL CARCINOGENESIS

合同的目标继续与最初商定的一样 与前一年合同的第一年一样 项目官员阿莫斯·帕尔默博士。SEMA。Inc.，提供动物护理和 为100只食蟹提供住房和兽医护理 猕猴(猕猴)和185只猕猴(Erythrocebus Patas)， 包括一群繁殖的帕塔斯猴。这些动物被登记在册 在经胎盘化学的连续研究方案中 致癌和促癌，起源于壁内 DCE比较癌变实验室研究计划， NCI，并由动物保护和使用委员会批准 分部，然后将其转交SEMA实施。承包商 为这些项目提供技术支持，包括 通过注射、抽血等方式给药 样本，动物的日常观察，定期称重，身体检查 检查和预防卫生措施，如结核病检测。这个 承包商保持AALAC认证，并聘请经验丰富的 灵长类兽医作为蜂群的监督人，为兽医提供 护理，进行任何必要的实验性手术，监督技术和 动物护理员工，并确保设施的运营和 动物的处理和治疗符合美国国立卫生研究院的护理指南 和使用实验动物。殖民地的最终目标是 提供有关化学物质作用机理的研究成果 非人灵长类动物中适合纳入的致癌物 发表在主要癌症研究期刊上的稿件。

The objectives of the contract continue to be as originally negotiated and as they were during the first year of the contract under the previous Project Officer, Dr. Amos Palmer. SEMA. Inc., provides animal care and housing and veterinary medical care for a colony of 100 cynomolgus monkeys (Macaca fascicularis) and 185 patas (Erythrocebus patas) monkeys, including a breeding colony of patas monkeys. These animals are enrolled in successive research protocols in transplacental chemical carcinogenesis and tumor promotion, that originate from the intramural research program of the Laboratory of Comparative Carcinogenesis, DCE, NCI, and are approved by the Animal Care and Use Committee of the Division before transmission to SEMA for implementation. The contractor provides technical support for these projects, including the administration of test substances by injection, the drawing of blood samples, daily observation of the animals, periodic weighing, physical examination, and preventive health measures such as TB testing. The contractor maintains AALAC accreditation and employs an experienced primate veterinarian as supervisor of the colony, to provide veterinary care, perform any necessary experimental surgery, supervise technical and animal care employees, and insure that the facility is operated and animals are handled and treated in compliance with the NIH Guide for Care and Use of Laboratory Animals. The ultimate objective of the colony is to provide research results on the mechanisms of action on chemical carcinogens in nonhuman primates that are suitable for inclusion in manuscripts for publication in primary cancer research journals.