MECHANISMS OF CHEMICAL CARCINOGENESIS

化学致癌机制

• 批准号: 3700978
• 负责人: RICHARD P BRADBURY
• 金额: $ 59.77万
• 依托单位: BIOQUAL, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-19 至 2000-12-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3700978
• 关键词: Cercopithecidae; Macaca fascicularis; animal breeding; animal care; animal colony; chemical carcinogenesis; embryo /fetus toxicology; placenta neoplasm; placental transfer; tumor promoters

The objectives of the contract continue to be as originally negotiated and as they were during the first year of the contract under the previous Project Officer, Dr. Amos Palmer. SEMA. Inc., provides animal care and housing and veterinary medical care for a colony of 100 cynomolgus monkeys (Macaca fascicularis) and 185 patas (Erythrocebus patas) monkeys, including a breeding colony of patas monkeys. These animals are enrolled in successive research protocols in transplacental chemical carcinogenesis and tumor promotion, that originate from the intramural research program of the Laboratory of Comparative Carcinogenesis, DCE, NCI, and are approved by the Animal Care and Use Committee of the Division before transmission to SEMA for implementation. The contractor provides technical support for these projects, including the administration of test substances by injection, the drawing of blood samples, daily observation of the animals, periodic weighing, physical examination, and preventive health measures such as TB testing. The contractor maintains AALAC accreditation and employs an experienced primate veterinarian as supervisor of the colony, to provide veterinary care, perform any necessary experimental surgery, supervise technical and animal care employees, and insure that the facility is operated and animals are handled and treated in compliance with the NIH Guide for Care and Use of Laboratory Animals. The ultimate objective of the colony is to provide research results on the mechanisms of action on chemical carcinogens in nonhuman primates that are suitable for inclusion in manuscripts for publication in primary cancer research journals.

合同的目标继续是最初谈判的 就像在合同的第一年一样 项目官员Amos Palmer博士。 Sema。 Inc.提供动物护理和 100 cynomolgus殖民地的住房和兽医医疗 猴子（Macaca fascicularis）和185个Patas（erythrocebus patas）猴子， 包括Patas猴子的繁殖殖民地。 这些动物被招募 在移植化学的连续研究方案中 癌变和肿瘤促进，源自壁内 比较致癌实验室的研究计划，DCE， NCI，并获得动物护理和使用委员会的批准 在传输到SEMA之前的划分进行实施。 承包商 为这些项目提供技术支持，包括 通过注射来施用测试物质，绘制血液 样品，每天观察动物，周期性称重，物理 检查和预防性健康措施，例如结核病测试。 这 承包商保持AALAC认证并雇用经验丰富的 灵长类动物兽医作为殖民地的主管，提供兽医 护理，进行任何必要的实验手术，监督技术和 动物护理员工，并确保该设施运营并 符合《 NIH护理指南》处理并处理动物 并使用实验室动物。 殖民地的最终目标是 提供有关化学作用机制的研究结果 非人类灵长类动物的致癌物，适合纳入 初级癌症研究期刊上出版的手稿。