MECHANISMS OF CHEMICAL CARCINOGENESIS

合同的目标仍然与最初谈判的目标相同 在合同的第一年， 项目官员，阿莫斯·帕尔默博士 SEMA。股份有限公司、提供动物护理， 100只食蟹猴群体的圈养和兽医医疗护理 猴（Macaca fascicularis）和185只猴（Erythrocebus patas）， 包括一个巴布亚猴的繁殖地 这些动物被登记 在经胎盘化学物质的连续研究方案中， 致癌和肿瘤促进，起源于壁内 比较致癌实验室的研究计划，DCE， NCI，并由动物护理和使用委员会批准， 在传输给SEMA执行之前进行划分。 承包商 为这些项目提供技术支持，包括 供试品注射给药、抽血 样品、每日观察动物、定期称重、物理 检查和预防性健康措施，如结核病检测。 的 承包商保持AALAC认证，并聘请经验丰富的 灵长类动物兽医作为殖民地的主管，提供兽医服务 护理，进行任何必要的实验手术，监督技术和 动物护理员工，并确保设施的运作， 按照NIH护理指南处理和治疗动物 实验动物的使用。 殖民地的最终目标是 提供关于化学品作用机制的研究结果， 非人类灵长类动物中的致癌物，适合列入 在主要癌症研究期刊上发表的手稿。

The objectives of the contract continue to be as originally negotiated and as they were during the first year of the contract under the previous Project Officer, Dr. Amos Palmer. SEMA. Inc., provides animal care and housing and veterinary medical care for a colony of 100 cynomolgus monkeys (Macaca fascicularis) and 185 patas (Erythrocebus patas) monkeys, including a breeding colony of patas monkeys. These animals are enrolled in successive research protocols in transplacental chemical carcinogenesis and tumor promotion, that originate from the intramural research program of the Laboratory of Comparative Carcinogenesis, DCE, NCI, and are approved by the Animal Care and Use Committee of the Division before transmission to SEMA for implementation. The contractor provides technical support for these projects, including the administration of test substances by injection, the drawing of blood samples, daily observation of the animals, periodic weighing, physical examination, and preventive health measures such as TB testing. The contractor maintains AALAC accreditation and employs an experienced primate veterinarian as supervisor of the colony, to provide veterinary care, perform any necessary experimental surgery, supervise technical and animal care employees, and insure that the facility is operated and animals are handled and treated in compliance with the NIH Guide for Care and Use of Laboratory Animals. The ultimate objective of the colony is to provide research results on the mechanisms of action on chemical carcinogens in nonhuman primates that are suitable for inclusion in manuscripts for publication in primary cancer research journals.