PRECHRONIC STUDIES OF DIPHENYLGUANIDINE

二苯胍的慢性研究

• 批准号: 2311414
• 负责人: LOUIS T MULLIGAN
• 金额: $ 29.37万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2311414
• 关键词: PRECHRONIC; STUDIES; DIPHENYLGUANIDINE

1, 3 Diphenylguanidine was nominated for testing by NCI because of the potential human exposure during production and use (rubber vulcanization) and because of lack of sufficient toxicity data for the guanidine class of chemicals. The objectives of the planned prechronic (14-day & 13-week) dosed feed studies in rats and mice are: 1. To characterize the toxicity associated with the repeated exposure to the chemical, the "no-effect-level", differences in sensitivity between sexes and species and the slope of the dose response curve. 2. To select the proper doses for use in a 2-year study to be designed for determining the carcinogenic potential of this chemical. The dosed feed route of administration was selected because human exposure could occur through this route and because the chemical is readily absorbed by rodents following consumption.

1，3-二苯基胍被NCI提名进行测试，因为 生产和使用过程中的潜在人体接触（橡胶硫化） 由于缺乏足够的胍类毒性数据， 化学物质。 计划的慢性前（14天和13周）给药饲料的目的 在大鼠和小鼠中的研究是：1.描述相关毒性 随着反复暴露于化学品，“无影响水平”， 性别和物种之间的敏感性差异以及 剂量反应曲线2.选择合适的剂量用于2年 研究旨在确定这种致癌潜力， 化工有限 选择给药饲料途径是因为人类 接触可能通过这一途径发生，因为化学品是 在食用后容易被啮齿动物吸收。