PRECHRONIC STUDIES OF DIPHENYLGUANIDINE

1，3-二苯基胍被NCI提名为检测对象，因为 生产和使用过程中潜在的人体接触(橡胶硫化) 而且由于缺乏足够的金刚烷类的毒性数据 化学物质。 计划的慢性前期(14天和13周)配料的目标 在大鼠和小鼠身上的研究是：1.表征相关的毒性 随着化学物质的反复暴露，“无影响水平”， 性别和物种间敏感度的差异以及 剂量反应曲线。2.选择合适的剂量在两年内使用 为确定这种物质的致癌潜力而设计的研究 化学药品。 剂量饲料给药途径的选择是因为人类 暴露可能通过这种途径发生，因为这种化学物质 在食用后很容易被啮齿动物吸收。

1, 3 Diphenylguanidine was nominated for testing by NCI because of the potential human exposure during production and use (rubber vulcanization) and because of lack of sufficient toxicity data for the guanidine class of chemicals. The objectives of the planned prechronic (14-day & 13-week) dosed feed studies in rats and mice are: 1. To characterize the toxicity associated with the repeated exposure to the chemical, the "no-effect-level", differences in sensitivity between sexes and species and the slope of the dose response curve. 2. To select the proper doses for use in a 2-year study to be designed for determining the carcinogenic potential of this chemical. The dosed feed route of administration was selected because human exposure could occur through this route and because the chemical is readily absorbed by rodents following consumption.