PRECHRONIC STUDIES OF DIPHENYLGUANIDINE

二苯胍的慢性研究

• 批准号: 2311419
• 负责人: LOUIS T MULLIGAN
• 金额: $ 1.9万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2311419
• 关键词: PRECHRONIC; STUDIES; DIPHENYLGUANIDINE

1, 3 Diphenylguanidine was nominated for testing by NCI because of the potential human exposure during production and use (rubber vulcanization) and because of lack of sufficient toxicity data for the guanidine class of chemicals. The objectives of the planned prechronic (14-day & 13-week) dosed feed studies in rats and mice are: 1. To characterize the toxicity associated with the repeated exposure to the chemical, the "no-effect-level", differences in sensitivity between sexes and species and the slope of the dose response curve. 2. To select the proper doses for use in a 2-year study to be designed for determining the carcinogenic potential of this chemical. The dosed feed route of administration was selected because human exposure could occur through this route and because the chemical is readily absorbed by rodents following consumption.

1, 3 二苯胍被 NCI 提名进行测试，因为 生产和使用过程中潜在的人体接触（橡胶硫化） 并且由于缺乏足够的胍类毒性数据 化学品。 计划的慢性前期（14 天和 13 周）剂量喂养的目标 在大鼠和小鼠中进行的研究包括： 1. 表征相关毒性 随着反复接触该化学品，“无影响水平”， 性别和物种之间敏感性的差异以及斜率 剂量反应曲线。 2. 选择2年使用的合适剂量 旨在确定该物质的致癌潜力的研究 化学。 选择定量饲料给药途径是因为人类 暴露可能通过此途径发生，并且因为该化学品是 啮齿类动物食用后很容易吸收。