SODIUM FLUORIDE, METHYLEUGENOL, & ANTHRAQUINONE

氟化钠、甲基丁香酚、

• 批准号: 2308836
• 负责人: MILTON HEITMANCIK
• 金额: $ 100万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1998-07-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308836
• 关键词: SODIUM; FLUORIDE; METHYLEUGENOL; ANTHRAQUINONE

The objective of this project is to determine the potential toxicity and carcinogenicity of sodium fluoride, methyleugenol, and optionally anthraquinone, by oral routes to Fischer 344 rats and B6C3F1 mice. The basic award for each chemical includes the development of analytical chemistry and dose formulation methods. Once these methods have been adequately developed, toxicity/carcinogenicity studies are to be conducted. Sodium fluoride -- 104-week study is to be conducted, involving seventy male rats, at 3 doses plus controls via dosed water, with interim sacrifices at 26 and 65 weeks. Special studies to be conducted at interim sacrifices include hematology; serum calcium, phosphorus, fluoride and alkaline phosphatase; and bone fluoride. Serum and bone fluoride concentrations are to be measured at terminal sacrifice. Whole body radiographs are to be made for all animals prior to necropsy throughout the study. Methyleugenol -- Toxicokinetic studies are to be conducted first to establish basic toxicokinetic parameters, to determine the extent of bioaccumulation and to determine actual internal doses after a single exposure. A 104-week study is to be conducted, involving fifty- animals/sex/species, at 3 doses plus controls via gavage. An additional 60 rats per sex are to be treated for 26 weeks at one dose for a stop study. Ten of these additional rats per sex are to be sacrificed at 26 weeks and the remainder will continue to seek 014 treated with vehicle only. Toxicokinetic studies are to be conducted during the chronic study to evaluate the effects of long term exposure and age on toxicokinetic parameters. Optional Study of Anthraquinone -- A 13-week study is to be conducted, involving ten animals/sex/species, at 5 doses plus controls via dosed feed. Special studies include hematology, clinical chemistries and urinalysis in rats, hematology in mice; SMVCE in rats and mice; toxicokinetic studies are to be conducted to establish basic toxicokinetic parameters, to determine the extent of bioaccumulation and to determine actual internal doses after a single exposure. 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls. Toxicokinetic studies are to be conducted during the chronic study to evaluate the effects of long term exposure and age on toxicokinetic parameters.

该项目的目的是确定潜在的毒性和 氟化钠、甲基丁香酚和任选的致癌性 蒽醌，通过口服途径给予 Fischer 344 大鼠和 B6C3F1 小鼠。 这 每种化学品的基本奖项包括分析开发 化学和剂量配制方法。 一旦这些方法都被 充分开发后，将进行毒性/致癌性研究。 氟化钠——将进行为期 104 周的研究，涉及 70 名 雄性大鼠，按 3 剂量加上通过定量水进行的对照，中间 26 周和 65 周时处死。 期间将进行专项研究 牺牲包括血液学；血清钙、磷、氟和 碱性磷酸酶；和骨氟化物。 血清和骨氟化物 浓度应在终末处死时测量。 全身 在整个过程中尸检前应对所有动物进行射线照相 学习。 甲基丁香酚——首先要进行毒代动力学研究 建立基本毒代动力学参数，以确定毒代动力学的程度 生物蓄积性并确定单次后的实际内部剂量 接触。 一项为期 104 周的研究将进行，涉及 50 名 动物/性别/物种，按 3 剂加灌胃法进行对照。 额外 60 每种性别的大鼠均应接受一次剂量治疗 26 周，然后停止研究。 每性别另外 10 只大鼠将在 26 周时处死， 其余的人将继续寻求只接受车辆治疗的 014。 毒代动力学研究将在长期研究期间进行 评估长期暴露和年龄对毒代动力学的影响 参数。 蒽醌的选择性研究——将进行为期 13 周的研究， 涉及 10 只动物/性别/物种，5 剂量加上通过定量饲料进行的对照。 特殊研究包括血液学、临床化学和尿液分析 大鼠、小鼠血液学；大鼠和小鼠的 SMVCE；毒代动力学研究是 进行建立基本毒代动力学参数，以确定 生物蓄积程度并确定实际内部剂量 单次曝光。 将进行为期 104 周的研究，涉及 50 只动物/性别/物种，研究时间为 3 个暴露浓度加上对照。 毒代动力学研究应 在长期研究期间进行，以评估长期影响 暴露和年龄对毒代动力学参数的影响。