SODIUM FLUORIDE, METHYLEUGENOL, & ANTHRAQUINONE

氟化钠、甲基丁香酚、

• 批准号: 2308829
• 负责人: PERRY J KURTZ
• 金额: $ 50万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1996-08-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308829
• 关键词: SODIUM; FLUORIDE; METHYLEUGENOL; ANTHRAQUINONE

The objective of this project is to determine the potential toxicity and carcinogenicity of sodium fluoride, methyleugenol, and optionally anthraquinone, by oral routes to Fischer 344 rats and B6C3F1 mice. The basic award for each chemical includes the development of analytical chemistry and dose formulation methods. Once these methods have been adequately developed, toxicity/carcinogenicity studies are to be conducted. Sodium fluoride -- 104-week study is to be conducted, involving seventy male rats, at 3 doses plus controls via dosed water, with interim sacrifices at 26 and 65 weeks. Special studies to be conducted at interim sacrifices include hematology; serum calcium, phosphorus, fluoride and alkaline phosphatase; and bone fluoride. Serum and bone fluoride concentrations are to be measured at terminal sacrifice. Whole body radiographs are to be made for all animals prior to necropsy throughout the study. Methyleugenol -- Toxicokinetic studies are to be conducted first to establish basic toxicokinetic parameters, to determine the extent of bioaccumulation and to determine actual internal doses after a single exposure. A 104-week study is to be conducted, involving fifty- animals/sex/species, at 3 doses plus controls via gavage. An additional 60 rats per sex are to be treated for 26 weeks at one dose for a stop study. Ten of these additional rats per sex are to be sacrificed at 26 weeks and the remainder will continue to seek 014 treated with vehicle only. Toxicokinetic studies are to be conducted during the chronic study to evaluate the effects of long term exposure and age on toxicokinetic parameters. Optional Study of Anthraquinone -- A 13-week study is to be conducted, involving ten animals/sex/species, at 5 doses plus controls via dosed feed. Special studies include hematology, clinical chemistries and urinalysis in rats, hematology in mice; SMVCE in rats and mice; toxicokinetic studies are to be conducted to establish basic toxicokinetic parameters, to determine the extent of bioaccumulation and to determine actual internal doses after a single exposure. 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls. Toxicokinetic studies are to be conducted during the chronic study to evaluate the effects of long term exposure and age on toxicokinetic parameters.

本项目的目的是确定潜在的毒性， 氟化钠、甲基丁香酚和任选的 蒽醌，通过口服途径给Fischer 344大鼠和B6 C3 F1小鼠。 的 每种化学品的基本奖励包括开发分析 化学和剂量配制方法。 一旦这些方法被 在充分开发的情况下，将进行毒性/致癌性研究。 氟化钠-将进行104周研究，涉及70名 雄性大鼠，3次给药+对照，通过给药水， 在26和65周时处死。 中期进行的特别研究 处死包括血液学;血清钙、磷、氟化物和 碱性磷酸酶和骨氟化物。 血清和骨氟 在终末处死时测量浓度。 全身 在整个尸检过程中，在尸检前对所有动物进行X光片检查。 study. 甲基丁香酚--首先进行毒代动力学研究， 建立基本毒代动力学参数，以确定 生物累积性，并确定单次照射后的实际体内剂量。 exposure. 将进行一项为期104周的研究，涉及50- 动物/性别/种属，3个剂量加对照组，灌胃。 另外60 每种性别的大鼠以一个剂量处理26周，用于停止研究。 在26周时，每种性别处死10只额外大鼠， 其余的将继续寻求014只与车辆处理。 在长期研究期间进行毒代动力学研究， 评价长期暴露和年龄对毒代动力学的影响 参数 蒽醌的选择性研究 将进行为期13周的研究， 涉及10只动物/性别/种属，5个剂量加对照组（通过给药饲料）。 特殊研究包括血液学，临床化学和尿液分析， 大鼠，小鼠血液学;大鼠和小鼠SMVCE;毒代动力学研究 以确定基本毒代动力学参数， 生物累积的程度，并确定在 一次曝光 104-将进行一周研究，涉及50只动物/性别/种属， 3个暴露浓度加对照。 毒代动力学研究将 在慢性研究期间进行，以评估长期 暴露和年龄对毒代动力学参数的影响。