Illuminating genomic dark matter to develop new interventions for parasites

照亮基因组暗物质以开发针对寄生虫的新干预措施

• 批准号: LP180101085
• 负责人: Prof Robin Gasser
• 金额: $ 85.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-11-06 至 2024-11-05
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180101085
• 关键词: Illuminating; genomic; dark; matter; develop

This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will translate into innovative technologies or products to ameliorate the burden of parasites in livestock animals. Expected socioeconomic benefits include lifting Australia’s scientific knowledge base, reputation in biology and biotechnology, livestock production and investment in translational research.

该项目旨在使用领先的后基因组学方法解开寄生虫的分子基础。这项研究希望探索基因组中的基因组“暗物质”，以发现寄生虫如何生存和引起疾病。由此产生的对控制寄生虫的分子机制和过程的理解的转变将导致破坏复杂的寄生虫-宿主关系的新方法，这将转化为创新技术或产品，以减轻家畜动物中寄生虫的负担。预期的社会经济效益包括提升澳大利亚的科学知识基础，在生物学和生物技术，畜牧业生产和转化研究投资方面的声誉。