CHRONIC TOXICITY--OXAZEPAM, PENTACHLOROPHENOL

慢性毒性--奥沙西泮、五氯苯酚

• 批准号: 2308437
• 负责人: PERRY J KURTZ
• 金额: $ 30万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-28 至 1995-03-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308437
• 关键词: CHRONIC; TOXICITY; OXAZEPAM; PENTACHLOROPHENOL

The objective of this project is to characterize dose-response relationships and toxicity of pentachlorophenol and oxazepam administered by dosed feed to rats. A 28-day study will be conducted for pentachlorophenol to provide data for the selection of doses to be used in the 2-year chronic study. For oxazepam, the 2-year chronic study will be conducted immediately since sufficient data for dose selection exist. All animals will be treated ad libitum during the course of the test period. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Plasma samples are to be obtained from test animals prior to and at 8 timepoints after a single gavage dose on the day of necropsy in both chronic studies. These samples will then be evaluated under separate contract for determination of plasma concentrations of the test compounds.

这个项目的目的是表征剂量反应