CHRONIC TOXICITY--OXAZEPAM, PENTACHLOROPHENOL

本项目的目标是描述剂量反应 施用五氯苯酚和奥沙西泮的相互关系和毒性 给老鼠喂食 将进行为期28天的研究， 五氯苯酚的使用剂量提供数据， 为期两年的慢性研究。 对于奥沙西泮，2年长期研究将 由于存在足够的剂量选择数据，因此立即进行。 所有 在试验期间，动物可自由采食。 在每次研究结束时，将对所有动物进行大体和显微镜检查。 组织病理学评价。 血浆样本将从试验中获得 当天单次灌胃给药前和给药后8个时间点的动物 在两项慢性研究中的尸检。 然后将对这些样本进行评估 根据单独的合同， 测试化合物。

The objective of this project is to characterize dose-response relationships and toxicity of pentachlorophenol and oxazepam administered by dosed feed to rats. A 28-day study will be conducted for pentachlorophenol to provide data for the selection of doses to be used in the 2-year chronic study. For oxazepam, the 2-year chronic study will be conducted immediately since sufficient data for dose selection exist. All animals will be treated ad libitum during the course of the test period. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Plasma samples are to be obtained from test animals prior to and at 8 timepoints after a single gavage dose on the day of necropsy in both chronic studies. These samples will then be evaluated under separate contract for determination of plasma concentrations of the test compounds.