TOXICITY STUDIES IN ANIMALS

动物毒性研究

• 批准号: 2308394
• 负责人: PERRY J KURTZ
• 金额: $ 198.75万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-30 至 1996-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308394
• 关键词: TOXICITY; STUDIES; ANIMALS

The purpose of this contract is to characterize the in vivo chemical toxicity in laboratory animals associated with short term exposures generally ranging from two to thirteen weeks. The studies performed under this contract will identify possible target organ(s) toxicity, similarities and differences in sensitivity between sexes and species of animals and dose response relationships. The data from these studies will also be used by the National Toxicology Program for establishment of dose levels of chemicals selected for subsequent long-term carcinogenicity studies.

本合同的目的是表征体内化学品 与短期接触有关的实验室动物毒性 一般为2 - 13周。 在以下条件下进行的研究 该合同将确定可能的靶器官毒性、相似性 性别和动物种类之间的敏感性差异， 剂量反应关系。 这些研究的数据也将被用于 由国家毒理学计划确定的剂量水平 选择用于后续长期致癌性研究的化学品。