HISTORY OF POSTTRANSFUSION NON-A, NON B HEPATITIS

乔治敦大学正在进行一项自然历史研究， 慢性非甲非乙型（NANB）肝炎。 的总体目标 这项为期五年的回顾性流行病学研究旨在确定 患者的临床、生化和组织学信息 发生输血后肝炎（PTH）的患者， 没有出现甲状旁腺激素的输血者。 具体 承包商必须：1）确定发生NANB的患者 先前完成的前瞻性研究中的PTH，以及 来自相同研究的对照组; 2）定位医疗 记录所有已确认的个人，并邀请幸存者 参加 这将包括初步重新评估（历史， 身体检查和生化测试）;以及3）遵循 两组患者每隔6个月进行一次为期3年的研究。 受试者定义为既往患有急性NANB PTH 研究（特别是输血传播病毒研究， 和退伍军人管理局合作研究 输血后肝炎）必须得到确认， 确认肝炎诊断和形式的数据（黄疸或 必须提供无黄疸剂。

Georgetown University is conducting a natural history study of chronic non-A, non-B (NANB) hepatitis. The overall objective of the five-year retrospective epidemiologic study is to determine the clinical, biochemical, and histological information on patients who developed posttransfusion hepatitis (PTH) and compare it with transfusion recipients who did not develop PTH. Specifically the contractor must: 1) identify patients who developed NANB PTH in previously completed prospective studies, as well as a group of controls from the same studies; 2) locate the medical records of all individuals identified and invite the survivors to participate. This would include an initial re-evaluation (history, physical examination, and biochemical tests); and 3) follow patients from both groups at six-month intervals for three years. Subjects defined as having had acute NANB PTH in previous studies (specifically, the Transfusion-Trans-mitted Virus Study, and the Veterans Administration Cooperative Study of Posttransfusion Hepatitis) must be identified and the supporting data confirming the diagnosis and form of hepatitis (icteric or anicteric) must be made available.