HISTORY OF POSTTRANSFUSION NON-A, NON B HEPATITIS

乔治城大学正在进行一项关于 慢性非甲非乙型肝炎。总的目标是 这项为期五年的回顾性流行病学研究旨在确定 患者的临床、生化和组织学信息 谁发展为输血后肝炎(PTH)并进行比较 未发生甲状旁腺激素的受血者。特指 承包商必须：1)确定出现NANB的患者 PTH在先前完成的前瞻性研究中，以及 来自相同研究的一组对照；2)定位医疗 所有确认身份的人的记录，并邀请幸存者 参与进来。这将包括初始重新评估(历史， 体检和生化测试)；以及3)以下 两组患者每隔6个月服药一次，连续服药3年。 被定义为既往患有急性NANB甲状旁腺激素的受试者 研究(特别是输血传播病毒研究， 和退伍军人管理合作研究 输血后肝炎)必须识别和支持 确认肝炎诊断和形式的资料(黄疸或 无黄褐症)必须提供。

Georgetown University is conducting a natural history study of chronic non-A, non-B (NANB) hepatitis. The overall objective of the five-year retrospective epidemiologic study is to determine the clinical, biochemical, and histological information on patients who developed posttransfusion hepatitis (PTH) and compare it with transfusion recipients who did not develop PTH. Specifically the contractor must: 1) identify patients who developed NANB PTH in previously completed prospective studies, as well as a group of controls from the same studies; 2) locate the medical records of all individuals identified and invite the survivors to participate. This would include an initial re-evaluation (history, physical examination, and biochemical tests); and 3) follow patients from both groups at six-month intervals for three years. Subjects defined as having had acute NANB PTH in previous studies (specifically, the Transfusion-Trans-mitted Virus Study, and the Veterans Administration Cooperative Study of Posttransfusion Hepatitis) must be identified and the supporting data confirming the diagnosis and form of hepatitis (icteric or anicteric) must be made available.