GLYCOLIPIDS AND CYTOTOXIC RESPONSE TO ANTINEOPLASTICS

糖脂和抗肿瘤药物的细胞毒性反应

• 批准号: 6329037
• 负责人: Myles C. Cabot
• 金额: $ 22.59万
• 依托单位: SAINT JOHN'S CANCER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-09 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6329037
• 关键词: antineoplastics; apoptosis; cell line; ceramides; cytotoxicity; enzyme inhibitors; glycosphingolipids; glycosylation; lipid metabolism; multidrug resistance; neoplasm /cancer pharmacology; pharmacokinetics

项目成果

Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNF-alpha-induced apoptosis.

• DOI: 10.1385/1-59259-667-3:177
• 发表时间: 2004
• 期刊: Methods in molecular biology
• 作者: Yong-Yu Liu;M. Cabot

Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics.

• DOI: 10.3892/ijo.15.3.541
• 发表时间: 1999-09
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Anthony Lucci;T. Han;Yong-Yu Liu;Armando E. Giuliano;M. Cabot

N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

• 发表时间: 2001-07
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Hongtao Wang;B. Maurer;Patrick Reynolds;M. Cabot

Enhanced de novo ceramide generation through activation of serine palmitoyltransferase by the P-glycoprotein antagonist SDZ PSC 833 in breast cancer cells.

通过 P-糖蛋白拮抗剂 SDZ PSC 833 激活乳腺癌细胞中的丝氨酸棕榈酰转移酶，增强从头生成神经酰胺。

• 发表时间: 2002
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7
• 作者: Wang,Hongtao;Giuliano,ArmandoE;Cabot,MylesC
• 通讯作者: Cabot,MylesC

SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein.

SDZ PSC 833 是一种耐药调节剂，通过独立于 P-糖蛋白的途径激活细胞神经酰胺的形成。

• DOI: 10.1016/s0304-3835(99)00353-5
• 发表时间: 2000
• 期刊: Cancer letters
• 影响因子: 9.7
• 作者: Goulding,CW;Giuliano,AE;Cabot,MC
• 通讯作者: Cabot,MC