NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE

神经行为老化——脑血管、心血管疾病的危险因素

• 批准号: 3802436
• 负责人: MARGIT L BLEECKER
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802436
• 关键词: aging; atherosclerosis; atherosclerotic plaque; cardiovascular disorder diagnosis; carotid artery; cerebrovascular disorder diagnosis; cognition; diet; disease /disorder proneness /risk; emotions; evoked potentials; exercise; human middle age (35-64); human old age (65+); human very old age (85+); locus of control; longitudinal human study; magnetic resonance imaging; nervous system disorder diagnosis; neuropsychological tests; neuropsychology; nutrition related tag; personality tests; physical fitness; psychomotor function; type A /type B personality; ultrasound blood flow measurement

During the past 4 years we have studied neurobehavioral performance in a group of 213 healthy men (N-92) and women (N-121) ranging in age from 40-90. They were selected for the absence of disease or other factors which would affect the central nervous system. Even with this strict selection criterion and comparable education levels considerable heterogeneity within age groups was observed for cognitive and psychomotor performance. This heterogeneity of normal aging may be separated into usual aging which results when extrinsic factors heighten the effects of aging alone and successful aging when extrinsic factors play a natural or positive role. The neurobehavioral battery employed consisted of mood and personality questionnaires, Types A Behavior Pattern, locus of control, neuropsychological battery and evoked potentials. This will be repeated when the subjects return with the addition of measures of risk factors associated with cerebrovascular disease, namely, blood pressure, heart disease (see Project 1) diabetes mellitus (fasting blood sugar) hyperlipidemia (e.g., cholesterol, LDL, HDL2, HDL3), alcohol and cigarette use. A neurological examination will include functional measures of cerebrovascular disease with quantitated carotid flow studies using a Doppler Volume Flow Meter. Duplex scanning and oculopneumoplethysmography will determines degree of stenosis and amount of atherosclerotic plaque in the carotid arteries. Whites matter changes in the central nervous system associated with vascular diseases in normal aging will be visualized by MRI of the brain. Results will be graded and correlated with risk factors, carotid flow studies and neurobehavioral performance. Exercise is known to effect circulatory function and mood. Its impact on neurobehavioral performance using the above crotocol will bs examined. In the study populations from Projects 1 and 2, 120 middles age to elderly men will be enrolled in a regular exercise program. Each subject maybe compared to his own baseline besides an appropriately matched sedentary group from men in the longitudinal study. Analysis will be performed to determine which variable or group of variables are the strongest predictor of neurobehavioral performance, namely, presence of risk factors for cerebrovascular disease, functional measures of carotid blood flow or cardiovascular fitness.

在过去的4年里，我们研究了神经行为表现， 在一组213名健康男性（N-92）和女性（N-121）中， 年龄在40-90岁之间。 他们被选中是因为没有疾病或 其他影响中枢神经系统的因素。 甚至 严格的选拔标准和同等的教育水平 水平相当大的异质性，在年龄组内观察到 认知和心理方面的表现。 这种异质性 正常老化可分为正常老化， 外在因素会加剧衰老的影响， 当外在因素起着自然或积极的作用时， 作用 所采用的神经行为电池包括情绪和 人格问卷，A型行为模式，人格特质 控制，神经心理电池和诱发电位。 这 将在受试者返回时重复，并添加 与脑血管疾病相关的危险因素的测量， 即血压、心脏病（见项目1）、糖尿病 糖尿病（空腹血糖）高脂血症（例如，胆固醇， LDL、HDL 2、HDL 3）、饮酒和吸烟。 神经 检查将包括脑血管功能测量 使用多普勒定量颈动脉血流研究的疾病 体积流量计 双功扫描和眼肺体积描记术 将决定狭窄程度和动脉粥样硬化的量 颈动脉斑块 白人问题的变化 正常人中枢神经系统血管病变 衰老将通过大脑的MRI可视化。 结果将 分级并与危险因素、颈动脉血流研究和 神经行为表现 众所周知，锻炼会产生 循环功能和情绪。 它对神经行为的影响 将检验使用上述crotocol的性能。 在 项目1和项目2的研究人群，120名中老年人 男性将参加定期锻炼计划。 每例受试者 也许与他自己的基线相比，除了一个适当匹配的 长期研究中的久坐组。 分析将 以确定哪个变量或变量组 神经行为表现的最强预测因子，即， 存在脑血管疾病的危险因素，功能性 测量颈动脉血流量或心血管健康。