BIOLOGICAL FACTORS RESPONSIBLE FOR NEUROBEHAVIORAL AGING
导致神经行为衰老的生物因素
基本信息
- 批准号:3120142
- 负责人:
- 金额:$ 16.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-07-01 至 1992-06-30
- 项目状态:已结题
- 来源:
- 关键词:aging atherosclerosis behavior biomarker cerebrovascular disorder diagnosis cerebrovascular disorders cognition disease /disorder proneness /risk electroencephalography electrophysiology female human middle age (35-64) human old age (65+) human subject learning magnetic resonance imaging male memory neuropsychological tests neuropsychology performance receptor sensorimotor system thermoreceptors
项目摘要
To improve our understanding of the underlying mechanisms
responsible for age-related ani gender-related differences in the
performance of cognitive and psychomotor tasks, biological factors
known to alter neural function will be measured and correlated with
performance. Psychomotor tests known to be affect by age and
gender will be administered to 100 healthy men and women ranging
in age from 40 to 70+ years. The neurobehavioral battery will
include measures of verbal memory and learning, motor speed and
sensory-motor performance besides mood and personality profile.
In addition, questionnaires for demographic information, medical
history, hobbies and life long training history and a neurological
examination will be assessed. We hypothesize that early,
asymptomatic cerebrovascular disease as indicated by the presence
of risk factors are biological markers of altered cerebrovascular
function modulates neuropsychological performance. Risk factors
for cerebrovascular disease, namely height/weight, blood pressure,
heart disease (EKG), diabetes mellitus (fasting blood glucose)
hyperlipidemia (e.g., cholesterol, LDL, HDL2, HDL3), alcohol and
cigarette use will be measured. Cerebrovascular function will be
quantitated with carotid flow studies using a Doppler Volume Flow
Meter. The quantity and composition of atherosclerotic plaque in
the carotid arteries will be quantitated with duplex scanning.
White matter changes in the central nervous system believed to be
secondary to cerebrovascular disease in normal aging will be
visualized by using magnetic resonance imaging (MRI) of the brain.
Electrophysiologic correlates of cerebral atherosclerosis will be
determined with quantitative electroencephalography using power
spectral analysis to be correlated with the other cerebrovascular
measures and neurobehavioral performance. A second hypothesis is
that age-related gender differences in motor speed (simple reaction
time and finger tapping) are due in part to differences in physical
activity. In the past physical activity has usually been obtained
by self-report. We propose to accurately measure maximal aerobic
capacity (VO2 max) and correlate the results with measures of motor
speed. The third hypothesis is that alterations in peripheral
sensory receptors (vibration, thermal perception thresholds) in
the fingertips is an important mechanism responsible for age-
related gender differences in sensory-motor performance (Purdue
Pegboard). Using this approach we hope to determine the important
mechanisms responsible for age-related and gender-related
differences in verbal memory and learning, motor speed and sensory-
motor-performance.
为了提高我们对潜在机制的理解
负责与年龄有关的和与性别有关的差异,
认知和心理任务的表现,生物因素
将测量已知改变神经功能的药物,并与
性能 心理测试已知受年龄和
将对100名健康男性和女性进行性别分析,
年龄从40岁到70岁以上。 神经行为电池将
包括言语记忆和学习,运动速度和
除了情绪和人格特征外,还有感觉运动表现。
此外,还提供人口统计信息、医疗信息的调查问卷
历史,爱好和终身训练史和神经系统
考试将进行评估。 我们假设早期,
无症状性脑血管疾病,
的危险因素是改变脑血管的生物标志物
功能调节神经心理学表现。 危险因素
对于脑血管疾病,即身高/体重,血压,
心脏病(EKG)、糖尿病(空腹血糖)
高脂血症(例如,胆固醇、LDL、HDL 2、HDL 3)、酒精和
香烟的使用将被衡量。 脑血管功能将
使用多普勒容积血流(Doppler Volume Flow)进行颈动脉血流研究定量
米 动脉粥样硬化斑块的数量和组成
颈动脉将用双功扫描定量。
中枢神经系统的白色物质变化被认为是
继发性脑血管病在正常衰老过程中
通过使用大脑的磁共振成像(MRI)可视化。
脑动脉粥样硬化的电生理相关性将是
使用功率定量脑电图测定
频谱分析与其他脑血管相关
测量和神经行为表现。 第二个假设是
与年龄相关的运动速度(简单反应)的性别差异
时间和手指敲击)部分是由于物理差异
活动 在过去,身体活动通常是通过
自我报告。 我们建议准确测量最大有氧运动
容量(VO 2 max),并将结果与运动指标相关联
速度 第三个假设是,外周神经系统的改变,
感觉感受器(振动,热感知阈值),
指尖是决定年龄的重要机制
感觉运动表现的相关性别差异(普渡大学
Pegboard)。 通过这种方法,我们希望确定重要的
负责与年龄和性别有关的
在语言记忆和学习,运动速度和感觉上的差异,
电机性能
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARGIT L BLEECKER其他文献
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{{ truncateString('MARGIT L BLEECKER', 18)}}的其他基金
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3817810 - 财政年份:
- 资助金额:
$ 16.61万 - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3813849 - 财政年份:
- 资助金额:
$ 16.61万 - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3809083 - 财政年份:
- 资助金额:
$ 16.61万 - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3802436 - 财政年份:
- 资助金额:
$ 16.61万 - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBRO-/CARDIOVASCULAR DISEASE
神经行为老化——脑/心血管疾病的危险因素
- 批准号:
3789997 - 财政年份:
- 资助金额:
$ 16.61万 - 项目类别:
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