NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE

神经行为老化——脑血管、心血管疾病的危险因素

基本信息

  • 批准号:
    3817810
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

During the past 4 years we have studied neurobehavioral performance in a group of 213 healthy men (N-92) and women (N-121) ranging in age from 40-90. They were selected for the absence of disease or other factors which would affect the central nervous system. Even with this strict selection criterion and comparable education levels considerable heterogeneity within age groups was observed for cognitive and psychomotor performance. This heterogeneity of normal aging may be separated into usual aging which results when extrinsic factors heighten the effects of aging alone and successful aging when extrinsic factors play a natural or positive role. The neurobehavioral battery employed consisted of mood and personality questionnaires, Types A Behavior Pattern, locus of control, neuropsychological battery and evoked potentials. This will be repeated when the subjects return with the addition of measures of risk factors associated with cerebrovascular disease, namely, blood pressure, heart disease (see Project 1) diabetes mellitus (fasting blood sugar) hyperlipidemia (e.g., cholesterol, LDL, HDL2, HDL3), alcohol and cigarette use. A neurological examination will include functional measures of cerebrovascular disease with quantitated carotid flow studies using a Doppler Volume Flow Meter. Duplex scanning and oculopneumoplethysmography will determines degree of stenosis and amount of atherosclerotic plaque in the carotid arteries. Whites matter changes in the central nervous system associated with vascular diseases in normal aging will be visualized by MRI of the brain. Results will be graded and correlated with risk factors, carotid flow studies and neurobehavioral performance. Exercise is known to effect circulatory function and mood. Its impact on neurobehavioral performance using the above crotocol will bs examined. In the study populations from Projects 1 and 2, 120 middles age to elderly men will be enrolled in a regular exercise program. Each subject maybe compared to his own baseline besides an appropriately matched sedentary group from men in the longitudinal study. Analysis will be performed to determine which variable or group of variables are the strongest predictor of neurobehavioral performance, namely, presence of risk factors for cerebrovascular disease, functional measures of carotid blood flow or cardiovascular fitness.
在过去的四年里,我们研究了神经行为表现

项目成果

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MARGIT L BLEECKER其他文献

MARGIT L BLEECKER的其他文献

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{{ truncateString('MARGIT L BLEECKER', 18)}}的其他基金

BIOLOGICAL FACTORS RESPONSIBLE FOR NEUROBEHAVIORAL AGING
导致神经行为衰老的生物因素
  • 批准号:
    3120142
  • 财政年份:
    1989
  • 资助金额:
    --
  • 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
  • 批准号:
    3813849
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
  • 批准号:
    3809083
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
  • 批准号:
    3802436
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBRO-/CARDIOVASCULAR DISEASE
神经行为老化——脑/心血管疾病的危险因素
  • 批准号:
    3789997
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

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