NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
基本信息
- 批准号:3817810
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:aging atherosclerosis cardiovascular disorder diagnosis carotid artery cerebrovascular disorder diagnosis cognition diet disease /disorder proneness /risk emotions evoked potentials exercise human middle age (35-64) human old age (65+) human very old age (85+) locus of control longitudinal human study magnetic resonance imaging nervous system disorder diagnosis neuropsychological tests neuropsychology nutrition related tag personality tests physical fitness psychomotor function type A /type B personality ultrasound blood flow measurement
项目摘要
During the past 4 years we have studied neurobehavioral performance
in a group of 213 healthy men (N-92) and women (N-121) ranging in
age from 40-90. They were selected for the absence of disease or
other factors which would affect the central nervous system. Even
with this strict selection criterion and comparable education
levels considerable heterogeneity within age groups was observed
for cognitive and psychomotor performance. This heterogeneity of
normal aging may be separated into usual aging which results when
extrinsic factors heighten the effects of aging alone and
successful aging when extrinsic factors play a natural or positive
role. The neurobehavioral battery employed consisted of mood and
personality questionnaires, Types A Behavior Pattern, locus of
control, neuropsychological battery and evoked potentials. This
will be repeated when the subjects return with the addition of
measures of risk factors associated with cerebrovascular disease,
namely, blood pressure, heart disease (see Project 1) diabetes
mellitus (fasting blood sugar) hyperlipidemia (e.g., cholesterol,
LDL, HDL2, HDL3), alcohol and cigarette use. A neurological
examination will include functional measures of cerebrovascular
disease with quantitated carotid flow studies using a Doppler
Volume Flow Meter. Duplex scanning and oculopneumoplethysmography
will determines degree of stenosis and amount of atherosclerotic
plaque in the carotid arteries. Whites matter changes in the
central nervous system associated with vascular diseases in normal
aging will be visualized by MRI of the brain. Results will be
graded and correlated with risk factors, carotid flow studies and
neurobehavioral performance. Exercise is known to effect
circulatory function and mood. Its impact on neurobehavioral
performance using the above crotocol will bs examined. In the
study populations from Projects 1 and 2, 120 middles age to elderly
men will be enrolled in a regular exercise program. Each subject
maybe compared to his own baseline besides an appropriately matched
sedentary group from men in the longitudinal study. Analysis will
be performed to determine which variable or group of variables are
the strongest predictor of neurobehavioral performance, namely,
presence of risk factors for cerebrovascular disease, functional
measures of carotid blood flow or cardiovascular fitness.
在过去的四年里,我们研究了神经行为表现
项目成果
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MARGIT L BLEECKER其他文献
MARGIT L BLEECKER的其他文献
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{{ truncateString('MARGIT L BLEECKER', 18)}}的其他基金
BIOLOGICAL FACTORS RESPONSIBLE FOR NEUROBEHAVIORAL AGING
导致神经行为衰老的生物因素
- 批准号:
3120142 - 财政年份:1989
- 资助金额:
-- - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3813849 - 财政年份:
- 资助金额:
-- - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3809083 - 财政年份:
- 资助金额:
-- - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBROVASCOLAR, CARDIVASCULAR DISEASE
神经行为老化——脑血管、心血管疾病的危险因素
- 批准号:
3802436 - 财政年份:
- 资助金额:
-- - 项目类别:
NEUROBEHAVIORAL AGING--RISK FACTORS FOR CEREBRO-/CARDIOVASCULAR DISEASE
神经行为老化——脑/心血管疾病的危险因素
- 批准号:
3789997 - 财政年份:
- 资助金额:
-- - 项目类别:
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