BARBADOS INCIDENCE STUDY OF EYE DISEASES II

巴巴多斯眼病发病率研究 II

• 批准号: 2430372
• 负责人: MCRISTINA LESKE
• 金额: $ 105.1万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2430372
• 关键词: African Caribbean; aging; alcoholism /alcohol abuse; blindness; cardiovascular disorder; cataract; clinical research; cooperative study; diabetes mellitus; diabetic retinopathy; dietary supplements; disease /disorder etiology; disease /disorder proneness /risk; epidemiology; eye disorder diagnosis; eye fundus photography; eye refractometry; family genetics; gene environment interaction; glaucoma; glaucoma test; human middle age (35-64); human old age (65+); human population study; human subject; hypertension; interview; longitudinal human study; macular degeneration; nutrition related tag; pathologic process; statistics /biometry; tobacco abuse; vision tests; visual fields; visual perception

The proposed Barbados Incidence Study of Eye Diseases II (BISED II) aims to collect 9-year incidence and progression data on open-angle glaucoma (OAG) and age-related cataract in the predominantly black population of Barbados, West Indies, as well as to obtain natural history data on age- related macular changes and diabetic changes. OAG and cataract are the two major causes of blindness in populations of African origin, accounting for about half of visual loss. Despite their high prevalence and public health importance, data on blacks are limited and no clear explanation for the increased risk exists. Early macular changes were frequent in the BES. Although diabetic retinopathy was less common, about one-fifth of the population has diabetes, thus raising questions about risk factors for DR in a black population. BISED II provides a unique opportunity to obtain the first long term incidence and progression data on a large population- based cohort, as such longitudinal data are not available for black populations. BISED II will provide new information concerning natural history and underlying factors for these chronic, life-long eye diseases, to assist in understanding etiology, identifying groups at high risk, and developing strategies to control visual loss. A shorter follow-up is insufficient to provide this information. To achieve these aims, BISED II will re-examine the surviving cohort of the Barbados Eye Study (BES). The BES was conducted from 1988 to 1992 to measure prevalence and risk factors for OAG, cataract, age-related macular degeneration and diabetic retinopathy, while providing baseline data for further incidence measurements. The BES was followed by the Barbados Incidence Study of Eye Diseases (BISED; 1992-1997), which is determining 4-year incidence and progression for these conditions. High participation rates of 84% and 85% were achieved by BES and BISED, respectively, among the eligible cohort. The positive response of the cohort and the past experience gained in conducting BES and BISED enhance the feasibility of successful follow-up. Given the cohort size, follow-up rates of incidence and progression can be estimated with high precision. Given the high prevalence and incidence, a wide range of relative risks can be detected. In summary, the BES cohort is a unique resource to study the major causes of blindness and provides an opportunity to learn, for the first time, about their long-term patterns of occurrence in a black population. This information may assist to address major racial differences in prevalence and has important public health implications.

拟议的巴巴多斯眼病发病率研究 II (BISED II) 的目标 收集开角型青光眼 9 年的发病率和进展数据 (OAG) 和以黑人为主的人口中与年龄相关的白内障 巴巴多斯、西印度群岛，以及获得有关年龄的自然历史数据 相关的黄斑变化和糖尿病变化。 OAG和白内障是两个 非洲裔人群失明的主要原因，占 大约一半的视力丧失。尽管其患病率很高且公共卫生 重要性，关于黑人的数据有限，并且没有明确的解释 存在增加的风险。 BES 中早期黄斑变化很常见。 尽管糖尿病视网膜病变不太常见，但大约五分之一的人患有糖尿病视网膜病变。 人口患有糖尿病，因此引发了关于 DR 危险因素的疑问 在黑人人口中。 BISED II 提供了一个独特的机会来获得 第一个针对大量人群的长期发病率和进展数据- 基于队列，因为此类纵向数据不适用于黑人 人口。 BISED II 将提供有关自然的新信息 这些慢性、终生眼病的病史和潜在因素， 协助了解病因、识别高危人群，以及 制定控制视力丧失的策略。较短的后续行动是 不足以提供此信息。为了实现这些目标，BISED II 将重新检查巴巴多斯眼科研究（BES）的幸存队列。这 BES 于 1988 年至 1992 年间进行，旨在衡量患病率和风险因素 用于 OAG、白内障、年龄相关性黄斑变性和糖尿病 视网膜病变，同时为进一步的发病率提供基线数据 测量。 BES 之后进行了巴巴多斯眼病发病率研究 疾病（BISED；1992-1997），确定 4 年发病率和 这些条件的进展。参与率高达 84% 和 85% BES 和 BISED 分别在符合条件的队列中实现了这一目标。 群体的积极反应和过去获得的经验 开展 BES 和 BISED 增强了成功后续行动的可行性。 考虑到队列规模，发病率和进展的随访率可以 估计精度很高。鉴于患病率和发病率较高， 可以检测到广泛的相对风险。总之，BES 队列 是研究失明主要原因的独特资源，并提供 第一次了解他们的长期发展的机会 黑人群体中的发生模式。此信息可能会有所帮助 解决患病率方面的主要种族差异，并具有重要的公众意义 健康影响。