CONFERENCE ON COCAINE--EFFECTS ON THE DEVELOPING BRAIN

这次会议的题目是可卡因：对发育中的大脑的影响， 计划于1997年9月在华盛顿特区举行。 会议的首席调查员和主席是约翰·A。 哈维，博士，MCP哈尼曼医学院。联席主席 出席会议的是巴里·E·科索夫斯基，医学博士，哈佛大学博士 大学。这次会议将汇集250名儿科医生， 儿童神经学家，发育儿科医生，神经学家， 特殊教育顾问和公共政策专家。这个 本次会议的目的是审查目前对 出生前大脑发育中暴露于可卡因是如何改变的 大脑发育计划及其对大脑的影响 结构、功能与人的发展。已完成的估算 今天在美国出生的婴儿中有百分比暴露在 子宫内的可卡因。近期临床数据与结果的融合 在临床前(动物)模型中获得的结果表明 特殊的大脑结构和神经递质系统 特定的大脑功能，以及妥协的证据 妊娠期可卡因暴露后，中枢神经系统功能增强。 此外，最近的临床研究已经确定了环境 影响人脑出生后发育的因素，这可能 改变子宫内遭受的大脑侮辱的表达 接触可卡因。会议发言人将回顾已知的情况 关于分子、神经化学、生理学和 影响妊娠毒性的神经病理过程 可卡因暴露，并将确定行为和临床 与那次暴露的关联。临床与临床前的综合 数据可能会让科学家了解常见的机制 可卡因对发育的毒性的潜在方面 大脑。它将促进对以下问题的更广泛的理解 临床医生，以及激发关于识别 有效的相关、选择性治疗药物模型 干预，对公共政策的影响将是 讨论过。

The conference, Cocaine: Effects on the Developing Brain, is scheduled to take place in September, 1997, in Washington, D.C. The principal investigator and chair of the meeting is John A. Harvey, Ph.D., MCP Hahneman School of Medicine. The co-chair of the meeting will be Barry E. Kosofsky, M.D., Ph.D., Harvard University. The conference will bring together 250 pediatricians, child neurologists, developmental pediatricians, neuroscientists, special education consultants and public policy experts. The purpose of this meeting is to review the current understanding of how prenatal exposure of developing brain to cocaine alters program for brain development with consequence for brain structure, function and human development. An estimate done percent of infants born in the United States today are exposed to cocaine in utero. A recent convergence of clinical data with results obtained in preclinical (animal) models suggests the vulnerability of particular brain structures and neurotransmitter systems subserving particular brain functions, as well as evidence for compromise of more global CNS function following gestational cocaine exposure. In addition, recent clinical studies have identified environmental factors that affect developing human brain postnatally, which may alter the expression of brain insults sustained consequent to in utero cocaine exposure. Conference speakers will review what is known concerning the molecular, neurochemical, physiologic, and neuropathologic processes mediating the toxicity of gestational cocaine exposure, and will identify behavioral and clinical correlates of that exposure. The synthesis of clinical and preclinical data may inform scientists regarding common mechanisms underlying aspects of the toxicity of cocaine on the developing brain. It will foster a broader understanding of the problem for clinicians, as well as stimulate thinking regarding identification of relevant, selective therapeutic agents Models for effective intervention, and the implications for public policy will be discussed.