GORDON CONFERENCE ON POLYAMINES

描述：（申请人的描述）多胺、亚精胺和 精胺和它们二胺前体腐胺是脂肪族阳离子 对细胞生长和活力至关重要。 多胺的细胞水平 是由一个复杂的反馈控制网络精心管理的， 多胺的合成、吸收和降解。 异常积累的 多胺与异常生长状态如癌症，狼疮， 牛皮癣和其他。 与这些观察结果一致， 多胺生物合成对人类非洲昏睡病有效 和卡氏肺孢子虫感染，以及沿着细胞毒性多胺 类似物，在化疗和化疗中显示出作为抗肿瘤剂的前景。 预防性临床试验。 正在取得迅速的进展， 了解多胺在细胞关键区域的基本作用 生理学和分子生物学，包括细胞周期调控， 细胞凋亡、DNA稳定性和离子通道整流。 与此同时 在学术和商业中心， 在新的多胺类似物和抑制剂的开发和测试中， 多胺的合成、功能和运输。 本提案的目的 是为戈登研究会议筹集部分资金 多胺，这将提供一个场所，自由交换意见， 活跃的调查人员，从基本的 考虑多胺生理学的临床试验的疗效 多胺稳态调节的各种策略。 实现 会议计划将包括多胺会议 （a）细胞周期调控和 细胞凋亡;（B）癌基因和癌症;（c）细胞效应，如通过 使用抑制剂和转基因生物;（d）运输和体内平衡; (e)（f）多胺代谢的类似物和新概念 抗癌药物;（g）原生动物寄生虫;（h）多胺合成和 在植物中的功能;和（i）控制离子通道。 此外，发言人 和讨论领导人已被选定代表的多样性， 观点，并包括一个显着的一部分调查人员谁拥有 最近进入聚胺领域。 在戈登研究 会议传统，所有与会者都是参与者。 在这一领域， 与会者代表许多不同的机构，包括基础和 临床科学部门、医院、政府研究中心和 工业实验室，几乎平等分布在美国和 非美国调查员。 预计这种非正式的交流， 最近的成果和想法，以及由此产生的讨论，将提供 额外的指导，尽量减少重复工作，并加强进展 发展战略，以了解和控制肿瘤 疾病

DESCRIPTION: (Applicant's Description) The polyamines, spermidine and spermine, and their diamine precursor, putrescine, are aliphatic cations essential for cell growth and viability. Cellular levels of the polyamines are carefully managed by a complex web of feedback controls governing polyamine synthesis, uptake and degradation. Abnormal accumulations of the polyamines are associated with aberrant growth states such as cancer, lupus, psoriasis, and others. Consistent with these observations, inhibitors of polyamine biosynthesis are effective against human African sleeping sickness and Pneumocystis carinii infections, and along with cytotoxic polyamine analogs, are showing promise as antitumor agents in chemotherapeutic and c h e moprevention clinical trials. Rapid advances are being made in understanding the basic role that polyamines serve in critical areas of cell physiology and molecular biology, including cell cycle regulation, apoptosis, DNA stability, and ion channel rectification. At the same time there has been a surge of activity, in both academic and commercial centers, in the development and testing of new polyamine analogs and inhibitors of polyamine synthesis, function and transport. The objective of this proposal is to secure partial funding for a Gordon Research Conference on the subject of polyamines that will provide a venue for a free exchange of ideas between active investigators spanning this complete spectrum of interests from basic consideration of polyamine physiology to clinical trials of the efficacy of various strategies in modification of polyamine homeostasis. To achieve this goal the conference program will include sessions on polyamine involvement in the following areas: (a) Cell cycle regulation and apoptosis; (b) Oncogenes and cancer; (c) Cellular effects as demonstrated by use of inhibitors and transgenic organisms; (d) Transport and homeostasis; (e) Control of polyamine metabolism; (f) Analogs and new concepts for anticancer drugs; (g) Protozoan parasites; (h) Polyamine synthesis and function in plants; and (i) Control of ion channels. Further, the speakers and discussion leaders have been selected to represent a diversity of perspectives, and to include a significant portion of investigators who have recently entered into the polyamine field. In the Gordon Research Conference tradition, all attendees are participants. In this field the participants represent many diverse institutions, including basic and clinical science departments, hospitals, government research centers and industrial laboratories, with almost an equal distribution between US and non-US investigators. It is anticipated that such an informal exchange of recent results and ideas, and the discussions engendered, will provide additional direction, minimize duplication of effort, and enhance progress toward development of strategies to understand and control neoplastic disease.