GORDON CONFERENCE ON POLYAMINES

戈登多胺会议

• 批准号: 2331117
• 负责人: JOHN L A MITCHELL
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-11 至 1998-07-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2331117
• 关键词: biochemistry; cell biology; meeting /conference /symposium; polyamines; travel

DESCRIPTION: (Applicant's Description) The polyamines, spermidine and spermine, and their diamine precursor, putrescine, are aliphatic cations essential for cell growth and viability. Cellular levels of the polyamines are carefully managed by a complex web of feedback controls governing polyamine synthesis, uptake and degradation. Abnormal accumulations of the polyamines are associated with aberrant growth states such as cancer, lupus, psoriasis, and others. Consistent with these observations, inhibitors of polyamine biosynthesis are effective against human African sleeping sickness and Pneumocystis carinii infections, and along with cytotoxic polyamine analogs, are showing promise as antitumor agents in chemotherapeutic and c h e moprevention clinical trials. Rapid advances are being made in understanding the basic role that polyamines serve in critical areas of cell physiology and molecular biology, including cell cycle regulation, apoptosis, DNA stability, and ion channel rectification. At the same time there has been a surge of activity, in both academic and commercial centers, in the development and testing of new polyamine analogs and inhibitors of polyamine synthesis, function and transport. The objective of this proposal is to secure partial funding for a Gordon Research Conference on the subject of polyamines that will provide a venue for a free exchange of ideas between active investigators spanning this complete spectrum of interests from basic consideration of polyamine physiology to clinical trials of the efficacy of various strategies in modification of polyamine homeostasis. To achieve this goal the conference program will include sessions on polyamine involvement in the following areas: (a) Cell cycle regulation and apoptosis; (b) Oncogenes and cancer; (c) Cellular effects as demonstrated by use of inhibitors and transgenic organisms; (d) Transport and homeostasis; (e) Control of polyamine metabolism; (f) Analogs and new concepts for anticancer drugs; (g) Protozoan parasites; (h) Polyamine synthesis and function in plants; and (i) Control of ion channels. Further, the speakers and discussion leaders have been selected to represent a diversity of perspectives, and to include a significant portion of investigators who have recently entered into the polyamine field. In the Gordon Research Conference tradition, all attendees are participants. In this field the participants represent many diverse institutions, including basic and clinical science departments, hospitals, government research centers and industrial laboratories, with almost an equal distribution between US and non-US investigators. It is anticipated that such an informal exchange of recent results and ideas, and the discussions engendered, will provide additional direction, minimize duplication of effort, and enhance progress toward development of strategies to understand and control neoplastic disease.

描述：(申请人描述)多胺、亚精胺和 精胺及其二胺前体腐胺是脂肪族阳离子。 对细胞生长和存活至关重要。多胺的细胞水平 由复杂的反馈控制网络精心管理， 多胺的合成、吸收和降解。的异常堆积 多胺与异常生长状态有关，如癌症、狼疮、 牛皮癣等。与这些观察结果一致的是，抑制剂 多胺生物合成对人类非洲昏睡病有效 和卡氏肺孢子虫感染，以及细胞毒多胺 类似物在化疗和化学治疗中显示出作为抗肿瘤药物的前景 电子预防临床试验。正在取得突飞猛进的进展 了解多胺在细胞关键区域中的基本作用 生理学和分子生物学，包括细胞周期调节， 细胞凋亡、DNA稳定性和离子通道整流。在同一时间 学术和商业中心的活动激增， 在新的多胺类似物和抑制剂的开发和测试中 多胺的合成、功能和运输。这项提议的目的是 是为了获得戈登研究会议的部分资金 多胺将提供一个自由交流思想的场所 积极的调查人员从基本的兴趣范围到 多胺生理学在临床疗效试验中的考虑 多胺动态平衡修饰的各种策略。要实现 为了实现这一目标，会议方案将包括关于多胺的会议 参与下列领域：(A)细胞周期调节和 细胞凋亡；(B)癌基因与癌症；(C)细胞效应 使用抑制剂和转基因生物；(D)运输和动态平衡； (E)控制多胺代谢；(F)类似物和新概念 抗癌药物；(G)原生动物寄生虫；(H)多胺合成和 在植物中的功能；和(I)离子通道的控制。此外，演讲者 并选出了讨论领袖，以代表不同的 观点，并包括相当一部分调查人员 最近进入了多胺领域。在戈登研究中 会议的传统是，所有与会者都是参与者。在该领域中， 参与者代表许多不同的机构，包括基础和 临床科学系、医院、政府研究中心和 工业实验室，在美国和美国几乎平均分布 非美国调查人员。预计这样一次非正式的交流 最近的成果和想法，以及由此产生的讨论，将提供 额外的指导，最大限度地减少重复工作，并促进进展 了解和控制肿瘤的策略的发展 疾病。