2023 Cell Biology of Megakaryocytes and Platelets Gordon Research Conference and Gordon Research Seminar

2023巨核细胞和血小板细胞生物学戈登研究会议暨戈登研究研讨会

• 批准号: 10608747
• 负责人: ALESSANDRA BALDUINI
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608747
• 关键词: Academia; Address; Area; Basic Science; Biogenesis; Biology; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Platelets; Bone Marrow; Cardiovascular Diseases; Cells; Cellular biology; Clinical; Coagulation Process; Collaborations; Communication; Complex; Congenital Disorders; Coupled; Data; Dedications; Development; Devices; Diagnosis; Disease; Disseminated Malignant Neoplasm; Engineering; Enhancers; Environment; Feedback; Fostering; Functional disorder; Future; Goals; Growth; Hematological Disease; Hematopoiesis; Hematopoietic stem cells; Hemorrhage; Hemostatic function; Immunity; Inflammation; Influentials; Inherited; International; Malignant Neoplasms; Megakaryocytes; Mentors; Mission; Molecular; Myeloproliferative disease; Neoplasm Metastasis; Outcome; Pathogenicity; Pathway interactions; Patients; Platelet Count measurement; Play; Prevention; Process; Production; Publications; Recording of previous events; Research; Research Personnel; Risk; Role; Signal Transduction; Stem Cell Development; Surface; Thrombopoiesis; Thrombopoietin; Thrombosis; Update; career; cell type; design; diagnostic tool; experience; hematopoietic stem cell differentiation; improved; leukemia; lymphatic development; meetings; mimetics; new technology; novel; novel therapeutics; platelet function; prevent; receptor function; seal; symposium; therapeutic target; tumor; wound healing

PROJECT SUMMARY / ABSTRACT The biennial Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on the Cell Biology of Megakaryocytes and Platelets brings together current leaders, junior investigators and trainees working on the development and disorders of the megakaryocyte lineage. It is the premier international meeting in the field. Our scientific mission is to bridge the gap between researchers working on different aspects of the lineage, i.e. hematopoietic stem cells, megakaryocytes and platelets. This mission is more relevant than ever, as the interdependence between each cell type becomes increasingly clear, e.g. the role of megakaryocytes in stem cell development, and the impact of inflammation on megakaryocyte growth and platelet production. The overarching, aim of the GRC is to allow current and emerging leaders of the field to communicate unpublished data, thereby educating colleagues, promoting discussions and fostering collaborations. Specifically, the aims are to: 1. Highlight the extraordinary progress being made in our understanding of platelet function in the context of hemostasis, thrombosis, and inherited/ congenital platelet disorders. Talks will cover the state-of-the-art on platelet surface receptor function and control of coagulation, intracellular signaling, the development of new targets for antiplatelet therapy, and immense progress in diagnosis and treatment of platelet function disorders. 2. Discuss the latest unpublished research on the engineering of devices and approaches to evaluate platelet function and how platelets can be used in therapy and as diagnostic tools. 3. Evaluate newly described mechanisms of megakaryocyte maturation and platelet production. It is increasingly apparent that platelet production is a complex multifactorial process controlled by super enhancers as well as the bone marrow microenvironment. In a dedicated session, we will discuss this unique interplay between the megakaryocyte lineage and other cells in the bone marrow environment. 4. Discuss studies that push the field into new directions, including updates on new regulators of hematopoiesis and thrombopoiesis, new technologies to study platelets on a single cell level and in high throughput functional omics, and a dedicated session to discuss newly identified critically influential roles for platelets in metastatic cancer, and megakaryocytes in leukemias and myeloproliferative disorders. To optimize interaction between researchers, and based on feedback from past conferences, we have designed most sessions so that they feature talks on both platelets and megakaryocytes. We also decided to continue with a new format that was first implemented in 2017, with the incorporation of 11 short talks to be selected from abstracts embedded within each of the main sessions (eliminating the dedicated hot topics session). The strengths of applying cross-disciplinary approaches to research questions will be emphasized throughout the whole meeting, and both basic science and translational aspects of the field will be discussed.

项目摘要/摘要 两年一度的细胞生物学戈登研究会议(GRC)和戈登研究研讨会(GRS) 巨核细胞和血小板将现任领导人、初级调查人员和受训人员聚集在一起 巨核细胞系的发育和紊乱。它是世界上最重要的 菲尔德。我们的科学使命是弥合研究人员在不同方面工作的差距 血统，即造血干细胞、巨核细胞和血小板。这项任务比以往任何时候都更加重要， 随着每种细胞类型之间的相互依赖日益明显，例如，巨核细胞在 干细胞发展，以及炎症对巨核细胞生长和血小板生成的影响。这个 最重要的是，GRC的目标是允许该领域的现任和新兴领导人进行未发表的交流 数据，从而教育同事、促进讨论和促进合作。 具体地说，目标是： 1.强调在以下背景下我们在了解血小板功能方面取得的非凡进展 止血、血栓形成和遗传性/先天性血小板疾病。演讲将涉及最先进的 血小板表面受体功能与凝血调控、细胞内信号转导新进展 抗血小板治疗的靶点，以及在诊断和治疗血小板功能紊乱方面的巨大进展。 2.讨论最新未发表的关于评估血小板的设备和方法的工程学研究 以及如何将血小板用于治疗和诊断工具。 3.评价最新报道的巨核细胞成熟和血小板生成机制。它是 越来越明显的是，血小板的产生是一个由超级增强剂控制的复杂的多因素过程 以及骨髓微环境。在专门的会议中，我们将讨论这种独特的相互作用 巨核细胞系和骨髓环境中的其他细胞之间的关系。 4.讨论将该领域推向新方向的研究，包括新监管机构的最新情况 在单细胞水平和高水平研究血小板的新技术--造血术和造血术 吞吐量功能组学，以及专门的会议，讨论新确定的关键有影响力的角色 转移癌中的血小板，白血病和骨髓增生性疾病中的巨核细胞。 为了优化研究人员之间的互动，并根据过去会议的反馈，我们已经 大多数会议都设计成既有关于血小板的演讲，也有关于巨核细胞的演讲。我们还决定 继续采用2017年首次实施的新形式，将纳入11个简短的讲座 从嵌入每个主要会议的摘要中精选(取消专门的热门主题 会议)。将强调应用跨学科方法解决研究问题的优势。 在整个会议期间，将讨论该领域的基础科学和翻译方面的问题。