B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers

传染病、自身免疫和 B 细胞癌症背景下的 B 细胞生物学

• 批准号: 10683443
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-10 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683443
• 关键词: Abnormal Cell; Acceleration; Acute; Address; Affect; Affinity; Antibodies; Antibody Response; Antigens; Area; Autoimmune Diseases; Autoimmunity; B lymphoid malignancy; B-Cell Activation; B-Cell Antigen Receptor; B-Lymphocytes; Basic Science; Cell Compartmentation; Cell physiology; Cells; Cellular biology; Chronic; Clinical; Clinical Research; Collaborations; Colorado; Communicable Diseases; Development; Disease; Educational workshop; Environment; Fostering; Generations; HIV Infections; HIV vaccine; Health; Human; Immune; Immunity; Individual; Inflammation; International; Intrinsic factor; Knowledge; Learning; Malignant Neoplasms; Mature B-Lymphocyte; Mediator; Mentors; Methodology; Outcome; Participant; Pharmaceutical Preparations; Play; Productivity; Publishing; Research; Research Personnel; Role; Science; Scientist; Signal Transduction; Variant; antigen-specific T cells; cancer cell; clinical practice; clinical translation; design; immunoprophylaxis; improved; knowledge translation; multidisciplinary; next generation; pathogen; posters; programs; prospective; public health priorities; recurrent infection; response; symposium; systemic autoimmunity; vaccine development

ABSTRACT Support is requested for a Keystone Symposia conference entitled B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers, organized by Drs. Susan Pierce and Facundo Batista. The conference will be held in Keystone, Colorado from June 6 - 10, 2023. Effective B cell antibody responses are essential for human health and protection against deadly infectious diseases. However, B cell antibodies are also mediators of devastating autoimmune diseases, and, when released from normal control mechanisms, B cell malignancies are common; and many remain untreatable. It is also becoming evident that the mature B cell compartment is highly heterogeneous and that antigen-driven fates of individual B cells are dependent on several factors, including the affinity of the B cell receptor (BCR) and how the BCR is wired to the B cell’s activation machinery, along with the quality of the immune environment as defined by both antigen-specific T cells and innate immune cells responding to pathogen- derived signals. The generation of long-lived protective immunity versus B cell malignancies, or systemic autoimmunity, may represent the spectrum of outcomes resulting from variations in and interactions between these intrinsic factors and the surrounding context. If so, our ability to rationally manipulate B cell responses to develop vaccines against infectious diseases, as well as therapies for autoimmune diseases and B cell cancers, may be greatly accelerated by a detailed understanding of the fundamentals of B cell biology. The translation of this knowledge to clinical and basic research will allow the field to address the most pressing public health priorities of our times, ranging from acute and chronic infectious diseases to autoimmunity and B cell malignancies. Finally, this conference is being held jointly with the Keystone Symposia conference, HIV Vaccines, Immunoprophylaxis and Drugs. This pairing is ideal to discuss how B cell abnormalities contribute to HIV infection, especially in terms of the potential for antibody-based vaccine development. Participants from both conferences will have the opportunity to network through shared sessions, mealtimes, and evening poster sessions.

抽象的 在感染力的背景下，请求支持Keystone研讨会会议，名为B细胞生物学 由DRS组织的疾病，自身免疫性和B细胞癌。 Susan Pierce和Facundo Batista。这 会议将于2023年6月6日至10日在科罗拉多州的基斯通举行。 有效的B细胞抗体反应对于人类健康和防止致命感染至关重要 疾病。但是，B细胞抗体也是毁灭性自身免疫性疾病的介体，当 B细胞恶性肿瘤是从正常控制机制中释放出来的。许多人仍然无法治疗。 也有证据表明成熟的B细胞室是高度异质性的，并且抗原驱动 单个B细胞的命运取决于几个因素，包括B细胞受体的亲和力（BCR） 以及如何将BCR连接到B细胞的激活机械以及免疫的质量 环境由抗原特异性T细胞和先天免疫细胞响应于病原体 - 派生的信号。长期保护的免疫与B细胞恶性肿瘤或全身性生成 自身免疫性可能代表因变化和相互作用而产生的结果的范围 这些内在因素和周围环境。如果是这样，我们合理操纵B细胞反应的能力 开发针对传染病的疫苗以及自身免疫性疾病和B细胞的疗法 对B细胞生物学的基本面的详细理解，癌症可能会大大加快癌症。 将这些知识转换为临床和基础研究将使该领域能够解决最紧迫的问题 我们时代的公共卫生优先事项，从急性和慢性传染病到自身免疫和B 细胞恶性肿瘤。最后，该会议将与Keystone研讨会会议共同举行。 疫苗，免疫预防和药物。这种配对是讨论B细胞异常如何贡献的理想选择 艾滋病毒感染，特别是在基于抗体的疫苗开发的潜力方面。来自 这两个会议都将有机会通过共享的会议，进餐时间和晚间海报进行联网 会议。