MEETINGS ON THE ADIPOSE CELL & INSULIN ACTION SECRETION

关于脂肪细胞的会议

• 批准号: 2017862
• 负责人: IRA D. GOLDFINE
• 金额: $ 2万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-31 至 1997-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2017862
• 关键词: adipose tissue; biological signal transduction; hormone regulation /control mechanism; insulin; meeting /conference /symposium; travel

Important advances have been made in the areas of diabetes and adipose cell research in recent years, making conferences on these topics extremely timely. These concurrent meetings will be multidisciplinary, bringing together investigators from academia and industry representing cell biology, molecular biology, immunology and biochemistry, and the clinical disciplines of endocrinology and metabolism. The prime objective is to present new findings that will stimulate cross- fertilization among basic and clinical investigators sharing common interests in hormone secretion and signaling and mechanisms of human diseases. Diabetes mellitus is a disease characterized by hyperglycemia, unknown molecular defects that impair beta cell insulin secretion and peripheral insulin responsiveness. Dramatic progress in cell and molecular biology research has revealed a number of related components and mechanisms underlying key processes in Type II diabetes syndromes. Common cellular signaling elements that control disease and insulin action in liver, muscle and fat include: tyrosine kinases; GTP- binding proteins such as ras; and protein serine/threonine kinase cascades. Control of insulin secretion in beta cells involves many of these same components. The adipose cell and its parent adipose tissue represent unique experimental systems in which to understand the integration of various signaling pathways involved in the regulation of differentiation and development. Adipose cells are responsive to a remarkably wide range of hormones which elicit a host of well characterized responses, including cell/tissue growth and development, substrate transport, lipogenesis, lipolysis, and protein trafficking and secretion. Much of the characterization of the intracellular insulin signaling system and its disruption in diabetes has been worked out in adipose cells, due to the insulin responsiveness of the cells and the ease of obtaining an culturing them from both patients and experimental animals. Recent advances have highlighted the active role the adipose tissue plays in the altered metabolism of diabetes as well as the impact of hyperglycemia and hyperinsulinemia on cellular insulin action in the fat cell. Molecular mechanisms involved in various signaling pathways include G-protein regulated effector systems such as adenylyl cyclase and phospholipases, receptor-associated and cytosolic tyrosine kinases and phosphatases. Since there are important relationships between: 1) diabetes and obesity; and 2) signaling pathways involved in immune cell responses, insulin secretion and action, and adipose cell regulation, this meeting should provide a unique scientific form for basic and clinical investigators involved in studies of hormone action and secretion.

在糖尿病和脂肪肝领域取得了重要进展， 近年来的细胞研究，使这些主题的会议 非常及时。这些同时举行的会议将是多学科的， 汇集了来自学术界和工业界的调查人员， 细胞生物学、分子生物学、免疫学和生物化学， 内分泌和代谢临床学科。原 目的是提出新的发现，将刺激跨- 基础和临床研究者之间的交流 感兴趣的激素分泌和信号和机制的人类 疾病糖尿病是一种以 高血糖症，未知的分子缺陷损害β细胞胰岛素 分泌和外周胰岛素反应性。在以下方面取得了巨大进展： 细胞和分子生物学研究揭示了许多相关的 II型糖尿病的关键过程的组成部分和机制 综合征控制疾病的常见细胞信号元件， 胰岛素在肝脏、肌肉和脂肪中作用包括：酪氨酸激酶; GTP- 结合蛋白如ras和蛋白丝氨酸/苏氨酸激酶 瀑布β细胞中胰岛素分泌的控制涉及许多 这些相同的组件。脂肪细胞及其母体脂肪组织 代表了独特的实验系统，可以在其中理解 参与调节的各种信号通路的整合 的差异和发展。脂肪细胞对一种 非常广泛的激素， 表征的反应，包括细胞/组织生长和发育， 底物转运、脂肪生成、脂解和蛋白质运输 和分泌物。 细胞内的许多特征 胰岛素信号系统及其在糖尿病中的破坏已经被研究 由于细胞的胰岛素反应性，在脂肪细胞中出现 以及容易从患者获得培养物， 实验动物最近的进展突出了 脂肪组织也在糖尿病的代谢改变中起作用 高血糖和高胰岛素血症对细胞胰岛素的影响 在脂肪细胞中的作用。参与各种疾病的分子机制 信号通路包括G蛋白调节的效应子系统， 作为腺苷酸环化酶和磷脂酶，受体相关的， 胞质酪氨酸激酶和磷酸酶。由于有重要的 1）糖尿病和肥胖之间的关系;以及2）信号传导 参与免疫细胞反应、胰岛素分泌和 行动，和脂肪细胞调节，这次会议应该提供一个 为参与的基础和临床研究者提供独特的科学形式 研究激素的作用和分泌。