2023 Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar

摘要 我们请求对“纤连蛋白、整合素和相关分子”戈登研究会议的部分支持 (GRC) 和戈登研究研讨会 (GRS)，2023 年 2 月 4 日至 10 日在加利福尼亚州文图拉万豪酒店举行。这个 GRC 原定于 2021 年 2 月举行，但由于 COVID-19 对美国和非美国国家实施旅行限制 美国参与者决定将其推迟到 2023 年。这个“仅限亲自参加”的 GRC 的主要目标是 加深对细胞外基质 (ECM) 控制的生化和生物物理线索的了解 细胞 ECM 信号传导，从而调节细胞和组织的稳态。我们还将重点关注扰动如何 这种对话促进了目前已知 ECM 在其中发挥关键作用的疾病，例如纤维化和癌症。 将深入探讨描述细胞-ECM 粘附控制方式的最新研究。我们会 解决细胞如何感知和解释受体-ECM 相互作用；细胞-ECM 粘附是如何进行的 特别是在活细胞中可视化；以及细胞-ECM 通讯如何在疾病中受到干扰以及如何 这可能是治疗的目标。第二个目标是为培养下一代做出贡献 科学家，并促进该研究领域初级研究人员的职业生涯。 GRS 位于 GRC 之前 还将最大限度地为学员提供展示和讨论他们的研究以及获得指导的机会 以及来自知名科学家的交流机会。这两次会议都将汇集不同的细胞 ECM 研究人员和外部专家分享他们的最新工作，从而激发新想法并解决重要问题 该研究领域的问题。他们将产生新的合作，从而维持和扩大 领域，并为开发新的治疗策略提供新的机会。 GRC/GRS 将围绕 32 位受邀演讲者，其中包括从事前沿研究的年轻/中期研究人员 在会议主题中。除了已确定的受邀演讲者外，每场会议还将有演讲 来自研究生、博士后和早期职业研究人员。他们将从提交的摘要中选出 创造讨论最新发现的机会，并将令人兴奋的研究纳入口头报告 演示文稿。此外，GRS 中的两到三名最佳演讲者将被选在会议上进行简短演讲。 GRC。 GRS 将包括两场由该领域领军人物邀请的演讲以及从最多 50 位领域领军人物中选出的 12 场演讲。 参与者。这两个项目都将举办海报会议，以最大限度地进行科学讨论，其中一些将是 被选中进行会谈。本次会议的新主题包括机械传感和机械生物学；如何整合素 结构可以导致治疗工具的开发；最先进的显微镜研究整合素回收 和信号发送；纤维化疾病和癌症迁移/侵袭中细胞-ECM 相互作用。主题更新 例如张力感应和信号传导、细胞迁移机制以及健康中的粘附信号传导模型 和疾病也包括在内。总体而言，本次国际会议将展示该领域的重大进展 细胞-ECM相互作用研究领域，并将一如既往地成为该领域的开创性会议。

Abstract We request partial support for the “Fibronectin, Integrin, and Related Molecules” Gordon Research Conference (GRC) and Gordon Research Seminar (GRS), February 4-10, 2023 at the Marriot Hotel, Ventura, California. This GRC was scheduled for February 2021, but due to COVID-19-imposed travel restrictions for both US and non- US participants, a decision was made to postpone it to 2023. The primary goal of this `in person only' GRC is to increase understanding of how biochemical and biophysical cues from the extracellular matrix (ECM) control cell-ECM signaling, thus regulating cellular and tissue homeostasis. We will also focus on how perturbations in this dialogue promote diseases in which the ECM is now known to play a key role, such as fibrosis and cancer. The latest research that delineates the way cell-ECM adhesion is controlled will be explored in-depth. We will address how receptor-ECM interaction is sensed and interpreted by cells; how cell-ECM adhesion can be visualized particularly in living cells; and how cell-ECM communication becomes perturbed in diseases and how this may be targeted therapeutically. The second goal is to contribute to training the next generation of scientists, and to foster the careers of junior investigators in this research area. The GRS preceding the GRC will also maximize the opportunity for trainees to present and discuss their research, and to obtain mentoring and networking opportunities from established scientists. Both meetings will bring together diverse cell-ECM researchers and outside experts to share their latest work, thereby stimulating new ideas and solving important problems in this research area. They will generate new collaborations, thereby sustaining and expanding the field, and provide new opportunities to develop novel therapeutic strategies. The GRC/GRS will nucleate around 32 invited speakers that include young/mid-term investigators who are performing the cutting edge of research in the conference topic. In addition to the established invited speakers, each of the sessions will feature talks from graduate students, post-docs and early career investigators. They will be selected from submitted abstracts to create opportunities for discussion of late-breaking discoveries and incorporate exciting research as oral presentations. Moreover, two or three of the best speakers from the GRS will be selected for a short talk at the GRC. The GRS will include two invited lectures by leaders in the field and 12 talks selected from up to 50 of the participants. Both programs will hold poster sessions to maximize scientific discussion, some of which will be selected for talks. New topics for this conference include mechanosensing and mechanobiology; how integrin structures can lead to the development of therapeutic tools; state-of-the-art microscopy to study integrin recycling and signaling; and cell-ECM interactions in fibrotic diseases and cancer migration/invasion. Updates on topics such as tension-sensing and signaling, mechanisms of cell migration, and models of adhesion signaling in health and disease are also included. Overall, this international conference will showcase the major advances in the field of cell-ECM interactions research and will be, as it has always been, the seminal conference in the field.