2023 Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar

摘要 我们请求部分支持“纤连蛋白，整合素，和相关分子”戈登研究会议 (GRC)和戈登研究研讨会（GRS），2023年2月4日至10日在伯劳特酒店，文图拉，加州。这 GRC原定于2021年2月举行，但由于COVID-19对美国和非美国公民实施的旅行限制， 美国参与者，决定将其推迟到2023年。此“仅限本人”GRC的主要目标是 增加对细胞外基质（ECM）的生物化学和生物物理学线索如何控制 细胞-ECM信号传导，从而调节细胞和组织稳态。我们还将重点关注扰动如何在 这种对话促进了ECM现在已知发挥关键作用的疾病，如纤维化和癌症。 将深入探讨描绘细胞-ECM粘附控制方式的最新研究。我们将 解决受体-ECM相互作用是如何被细胞感知和解释的;细胞-ECM粘附如何被 特别是在活细胞中可视化;以及细胞-ECM通讯如何在疾病中受到干扰，以及如何在疾病中受到干扰。 这可以是治疗上的靶点。第二个目标是帮助培训下一代 科学家，并促进在这一研究领域的初级研究人员的职业生涯。GRC之前的GRS 还将最大限度地为学员提供机会，介绍和讨论他们的研究，并获得指导 和建立科学家网络的机会。这两次会议将汇集不同的细胞-细胞外基质 研究人员和外部专家分享他们的最新工作，从而激发新的想法和解决重要的 这个研究领域的问题。它们将产生新的合作，从而维持和扩大 领域，并提供新的机会，开发新的治疗策略。GRC/GRS将围绕 32位特邀演讲者，包括正在进行前沿研究的年轻/中期研究人员 在会议主题中。除了既定的特邀演讲者外，每个会议都将以讲座为特色 从研究生、博士后和早期职业调查人员。它们将从提交的摘要中选出 创造机会讨论最新的发现，并将令人兴奋的研究纳入口头 介绍。此外，大会亦会挑选两至三位来自“香港赛马会”的优秀讲者， GRC。GRS将包括该领域领导人的两次特邀演讲和从多达50个演讲中选出的12个演讲。 参与者这两个项目都将举行海报会议，以最大限度地提高科学讨论，其中一些将是 被选中参加会谈。这次会议的新主题包括机械传感和机械生物学;整合素如何 结构可以导致治疗工具的发展;最先进的显微镜研究整合素循环 和信号传导;以及纤维化疾病和癌症迁移/侵袭中的细胞-ECM相互作用。专题更新 例如张力感应和信号传导、细胞迁移机制和健康中的粘附信号传导模型 疾病也包括在内。总的来说，这次国际会议将展示 细胞外基质相互作用的研究领域，并将一如既往，在该领域的开创性会议。

Abstract We request partial support for the “Fibronectin, Integrin, and Related Molecules” Gordon Research Conference (GRC) and Gordon Research Seminar (GRS), February 4-10, 2023 at the Marriot Hotel, Ventura, California. This GRC was scheduled for February 2021, but due to COVID-19-imposed travel restrictions for both US and non- US participants, a decision was made to postpone it to 2023. The primary goal of this `in person only' GRC is to increase understanding of how biochemical and biophysical cues from the extracellular matrix (ECM) control cell-ECM signaling, thus regulating cellular and tissue homeostasis. We will also focus on how perturbations in this dialogue promote diseases in which the ECM is now known to play a key role, such as fibrosis and cancer. The latest research that delineates the way cell-ECM adhesion is controlled will be explored in-depth. We will address how receptor-ECM interaction is sensed and interpreted by cells; how cell-ECM adhesion can be visualized particularly in living cells; and how cell-ECM communication becomes perturbed in diseases and how this may be targeted therapeutically. The second goal is to contribute to training the next generation of scientists, and to foster the careers of junior investigators in this research area. The GRS preceding the GRC will also maximize the opportunity for trainees to present and discuss their research, and to obtain mentoring and networking opportunities from established scientists. Both meetings will bring together diverse cell-ECM researchers and outside experts to share their latest work, thereby stimulating new ideas and solving important problems in this research area. They will generate new collaborations, thereby sustaining and expanding the field, and provide new opportunities to develop novel therapeutic strategies. The GRC/GRS will nucleate around 32 invited speakers that include young/mid-term investigators who are performing the cutting edge of research in the conference topic. In addition to the established invited speakers, each of the sessions will feature talks from graduate students, post-docs and early career investigators. They will be selected from submitted abstracts to create opportunities for discussion of late-breaking discoveries and incorporate exciting research as oral presentations. Moreover, two or three of the best speakers from the GRS will be selected for a short talk at the GRC. The GRS will include two invited lectures by leaders in the field and 12 talks selected from up to 50 of the participants. Both programs will hold poster sessions to maximize scientific discussion, some of which will be selected for talks. New topics for this conference include mechanosensing and mechanobiology; how integrin structures can lead to the development of therapeutic tools; state-of-the-art microscopy to study integrin recycling and signaling; and cell-ECM interactions in fibrotic diseases and cancer migration/invasion. Updates on topics such as tension-sensing and signaling, mechanisms of cell migration, and models of adhesion signaling in health and disease are also included. Overall, this international conference will showcase the major advances in the field of cell-ECM interactions research and will be, as it has always been, the seminal conference in the field.