2023 Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar

摘要 我们请求部分支持戈登研究会议的“纤维连接蛋白、整合素和相关分子” (GRC)和戈登研究研讨会(GRS)，2023年2月4日至10日，在加州文图拉万豪酒店举行。这 GRC原定于2021年2月举行，但由于新冠肺炎对美国和非美国实施的旅行限制 美国与会者决定将其推迟到2023年。这个“仅限面对面”的GRC的主要目标是 增加对来自细胞外基质(ECM)的生化和生物物理信号如何控制的理解 细胞-ECM信号，从而调节细胞和组织的动态平衡。我们还将重点介绍微扰是如何 这种对话促进了目前已知ECM在其中发挥关键作用的疾病，如纤维化和癌症。 描述细胞-ECM黏附控制方式的最新研究将被深入探索。我们会 阐述受体-ECM相互作用如何被细胞感知和解释；细胞-ECM黏附如何 特别是在活细胞中的可视化；以及在疾病中细胞与细胞外基质的通讯如何变得混乱以及如何 这可能是治疗上的靶向。第二个目标是为培养下一代 并促进这一研究领域的初级调查人员的职业生涯。GRC之前的GRS 还将最大限度地为学员提供介绍和讨论他们的研究并获得指导的机会 以及来自知名科学家的网络机会。这两次会议将把不同的细胞-ECM聚集在一起 研究人员和外部专家分享他们的最新工作，从而激发新的想法，解决重要的 这一研究领域存在的问题。它们将产生新的协作，从而维持和扩大 并为开发新的治疗策略提供了新的机会。GRC/GRS将在周围成核 32位特邀演讲者，其中包括从事前沿研究的年轻/中期研究人员 在会议主题中。除了已确定的受邀演讲者外，每一场会议都将有演讲 来自研究生、博士后和早期职业调查人员。他们将从提交的摘要中挑选出来 创造机会讨论最新的发现，并将令人兴奋的研究作为口头研究 演示文稿。此外，来自GRS的两到三位最佳演讲者将被选为在 GRC。GRS将包括两个由该领域领导人邀请的讲座和12个演讲，这些演讲是从多达50个 参与者。这两个节目都将举行海报会议，以最大限度地进行科学讨论，其中一些将是 被选中参加会谈。这次会议的新主题包括机械传感和机械生物学；如何整合 结构可以导致治疗工具的发展；研究整合素循环的最先进的显微镜 以及细胞-细胞外基质相互作用在纤维化疾病和癌症转移/侵袭中的作用。关于主题的更新 如张力感应和信号传递、细胞迁移机制和黏附信号在健康中的模型 和疾病也包括在内。总体而言，这次国际会议将展示在 这是细胞-细胞外基质相互作用研究领域的最新进展，并将一如既往地成为该领域的开创性会议。

Abstract We request partial support for the “Fibronectin, Integrin, and Related Molecules” Gordon Research Conference (GRC) and Gordon Research Seminar (GRS), February 4-10, 2023 at the Marriot Hotel, Ventura, California. This GRC was scheduled for February 2021, but due to COVID-19-imposed travel restrictions for both US and non- US participants, a decision was made to postpone it to 2023. The primary goal of this `in person only' GRC is to increase understanding of how biochemical and biophysical cues from the extracellular matrix (ECM) control cell-ECM signaling, thus regulating cellular and tissue homeostasis. We will also focus on how perturbations in this dialogue promote diseases in which the ECM is now known to play a key role, such as fibrosis and cancer. The latest research that delineates the way cell-ECM adhesion is controlled will be explored in-depth. We will address how receptor-ECM interaction is sensed and interpreted by cells; how cell-ECM adhesion can be visualized particularly in living cells; and how cell-ECM communication becomes perturbed in diseases and how this may be targeted therapeutically. The second goal is to contribute to training the next generation of scientists, and to foster the careers of junior investigators in this research area. The GRS preceding the GRC will also maximize the opportunity for trainees to present and discuss their research, and to obtain mentoring and networking opportunities from established scientists. Both meetings will bring together diverse cell-ECM researchers and outside experts to share their latest work, thereby stimulating new ideas and solving important problems in this research area. They will generate new collaborations, thereby sustaining and expanding the field, and provide new opportunities to develop novel therapeutic strategies. The GRC/GRS will nucleate around 32 invited speakers that include young/mid-term investigators who are performing the cutting edge of research in the conference topic. In addition to the established invited speakers, each of the sessions will feature talks from graduate students, post-docs and early career investigators. They will be selected from submitted abstracts to create opportunities for discussion of late-breaking discoveries and incorporate exciting research as oral presentations. Moreover, two or three of the best speakers from the GRS will be selected for a short talk at the GRC. The GRS will include two invited lectures by leaders in the field and 12 talks selected from up to 50 of the participants. Both programs will hold poster sessions to maximize scientific discussion, some of which will be selected for talks. New topics for this conference include mechanosensing and mechanobiology; how integrin structures can lead to the development of therapeutic tools; state-of-the-art microscopy to study integrin recycling and signaling; and cell-ECM interactions in fibrotic diseases and cancer migration/invasion. Updates on topics such as tension-sensing and signaling, mechanisms of cell migration, and models of adhesion signaling in health and disease are also included. Overall, this international conference will showcase the major advances in the field of cell-ECM interactions research and will be, as it has always been, the seminal conference in the field.