VERMONT BREAST CANCER SURVEILLANCE SYSTEM

佛蒙特州的乳腺癌监测系统就是在这里提出的 合作协议申请成为多站点的一部分 美国国家癌症研究所乳腺癌监测联盟。我们的目标 是组织一个多学科的乳腺癌调查小组 与其他联盟站点的研究人员和NCI工作人员一起在 开展协作性乳腺癌监测研究。作为世界上最 在全国的农村州，佛蒙特州非常适合平衡更多的城市 目前在NCI联盟中有代表的站点。此外，使用一个 正在进行的全州范围的乳房X光检查-病理登记，以及强制执行的 基于SEER模型的国家癌症登记，我们的网站准备得很好 与目前的NCI财团网站保持同步，收集和 分析监控数据。本申请的具体目的是：(A) 建立全面的、有质量控制的全州监督 将访问现有记录并从其中收集新信息的系统 乳房X光检查设施，病理实验室，以及以人群为基础的 癌症登记；(B)促进乳腺癌研究合作和 基础研究人员、临床研究人员和应用人员之间的互动 佛蒙特州和NCI乳腺癌监测中心的研究人员 (C)研究乳癌手术方面的问题；及 通过进行系统研究进行筛查和诊断 评估筛查计划的有效性、效率和成本，并 诊断技术，因为它们与减少发病率和 乳腺癌死亡率。拟议研究的具体领域包括 改进乳房筛查的医疗决策模型的开发 成果(研究项目#1)和评估应用 超声引导下的乳腺活检和临床结果(研究项目 #2)。

The Vermont Breast Cancer Surveillance System is proposed in this cooperative agreement application to become part of the multi-site National Cancer Institute Breast Cancer Surveillance Consortium. Our goal is to organize a multi-disciplinary group of breast cancer investigators joining with researchers in other Consortium sites and NCI staff in conducting collaborative breast cancer surveillance research. As the most rural state in the nation, Vermont is well suited to balance more urban sites currently represented in the NCI Consortium. In addition, with an ongoing state-wide mammography-pathology registry coupled with a mandated state cancer registry based on the SEER model, our site is well prepared to keep pace with the present NCI Consortium sites in gathering and analyzing surveillance data. Specific aims of this application are: (a) to establish a comprehensive, quality controlled, state-wide surveillance system that will access existing records and collect new information from mammography facilities, pathology laboratories, and a population-based cancer registry; (b)to foster breast cancer research collaborations and interactions among basic researchers, clinical researchers and applied researchers in Vermont and in the NCI Breast Cancer Surveillance Consortium; and (c) to examine the operational aspects of breast cancer screening and diagnosis by conducting systematic research designed to assess the effectiveness, efficiency and cost of screening programs and diagnostic techniques as they relate to the reduction of morbidity and mortality from breast cancer. Specific areas of proposed research include the development of a medical decision model to improve breast screening outcomes (Research Project #1) and evaluating the application of ultrasound guided breast biopsy and clinical outcomes (Research Project #2).