CARET: THE SEATTLE STUDY CENTER

CARET是一项正在进行的双盲肺癌化学预防试验， 30 mg β-胡萝卜素和25000 在两个高危人群中每日给予棕榈酸视黄酯IU：（a）男性和 主要从保险公司招募的女性现吸烟者和前吸烟者 来源，和（B）广泛职业石棉暴露的男性 主要从就业来源招聘。我们记录 成功招募，良好的依从性，以及最小的副作用， 超过15，000名参与者在六个研究中心随机分组。通过 1993年4月30日，CARET随机抽取了4，000名接触石棉的工人， 超过所有五个CARET石棉中心的应计目标，11，105 烟瘾很大。西雅图和波特兰的吸烟人数已经超过了他们的重度吸烟者 目标，欧文是在轨道上实现其目标在1994年7月。期间 在最后五年期间，CARET将专注于保留，遵守 协议，确定端点，监控关键设计参数， 试验结束、分析和发表。预测表明 有14,240名吸烟者和4,010名石棉接触者， 到1998年2月，对114，100人-年的随访， 能够检测A.两个国家肺癌发病率降低23% 高风险人群合并，分别减少27%、49%、32%和35%， 吸烟者、女性吸烟者、男性吸烟者和接触石棉的亚组， 分别 西雅图研究中心有一个独特的责任， 最初吸烟者和石棉接触工人试点的参与者 研究，以及西雅图在CARET疗效队列中的份额。的 1985-1988年期间招募了1，845名试点参与者，1，524名（先锋队） （三）积极参与。这些先锋队的参与者是 密切监测，以评价可能与 研究维生素的累积剂量。西雅图学习中心 超过了吸烟者和石棉的CARET功效招募目标- 暴露的工人，部分原因是我们最近批准的招聘机会， 美国退休人员协会的成员。研究中心 将继续强调留住参与者和遵守 CARET协议。终点的集合，这将增加 在最后的四年里， 活动停止。我们的数据和处理部门将及时 向协调中心提交和核对数据。为 作为CARET最大的研究中心，我们将在分析中发挥突出作用 并公布CARET结果。

CARET is an ongoing double-blind lung cancer chemoprevention trial of the efficacy and safety of tide combination of 30 mg beta-carotene and 25,000 IU retinyl palmitate daily in two high-risk populations: (a) male and female current and former smokers recruited primarily from insurance-based sources, and (b)males with extensive occupational asbestos exposure recruited primarily from employment-based sources. We have documented successful recruitment, excellent adherence, and minimal side effects in over 15,000 participants randomized thus fur at six study centers. Through 30 April, 1993, CARET has randomized 4,000 asbestos-exposed workers, exceeding accrual goals at all five CARET asbestos centers, and 11,105 heavy smokers. Seattle and Portland have exceeded their heavy smoker goals, and Irvine is on track to achieve its goal in July 1994. During the final five-year period, CARET will focus on retention, adherence to protocol, ascertainment of endpoints, monitoring of key design parameters, closeout of the trial, and analysis and publication. Projections indicate that with 14,240 smokers and 4,010 asbestos-exposed participants and 114,100 person-years of follow-up through February 1998, CARET will be capable of detecting a. 23% reduction in lung cancer incidence in the two high-risk populations combined, and 27%, 49%, 32%, and 35% reductions in the smokers, female smokers, male smokers, and asbestos-exposed subgroups, respectively. The Seattle Study Center has a unique responsibility for following the participants in the original smoker and asbestos-exposed worker pilot studies, as well as Seattle's share of the CARET Efficacy cohort. Of the 1,845 Pilot participants recruited during 1985-1988, 1,524 (the Vanguard cohort) continued active participation. These Vanguard participants are monitored closely to evaluate toxicity potentially related to the cumulative dose of the study vitamins. The Seattle' Study Center has surpassed its CARET Efficacy recruitment goals of smokers and asbestos- exposed workers, in part due to our recently approved access to recruit members of the American Association of Retired Persons. The Study Center will continue to emphasize the retention of participants and adherence to the CARET protocol. The collection of endpoints, which will be increasing during the final four years, has also become more prominent as recruitment activities cease. Our data and processing unit will focus on timely submission and reconciliation of data with the Coordinating Center. As the largest study center of CARET, we will play a prominent role in analysis and publication of CARET results.