Development of an effective alcohol-free hand rub

开发有效的不含酒精的洗手液

• 批准号: 64228
• 金额: $ 6.27万
• 依托单位: AQUALUTION SYSTEMS LTD
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=64228
• 关键词: Development; effective; alcohol; free; hand

Many community and health-care associated infections are preventable through good hand hygiene i.e. cleaning hands at the right times and in the right way with the most suitable method. Indeed enhanced hand hygiene has been a key part of the government strategy to contain the Covid-19 pandemic.The optimum method of maintaining good hand hygiene is through use of soap and hot running water. However, this is not always possible, practical or convenient. This has led to a surge in the use of alcohol based hand rubs (ABHRs).ABHRs are not produced using standard ingredients nor do they have a standard / declared strength, despite a minimum 65% concentration being required for them to be effective. In addition these products rarely have usage instructions on the label, despite the fact that BSEN 1500 states that 6 ml (2 washes with 3ml each time) is the necessary dose. Different alcohols have a varying spectrum of target organisms and not all alcohols are effective against all pathogens. ABHRs can cause drying / cracking of hands and can sting if applied to broken skin. In addition they are flammable and can cause harm if ingested. They are not safe to use in all environments (eg primary schools, dementia care settings) and are not acceptable to people of certain faiths.This project focusses on creating a convenient and efficacious hand rub based on hypochlorous acid. Hypochlorous acid is produced by the mammalian body in response to pathogen attack. It is a fast acting and safe biocide which is effective against a wide range of pathogens (bacteria, viruses, yeasts, moulds, protozoa, spores). It is already used in the healthcare sector in liquid form (hard surface disinfection and hand sanitation) however professional users and consumers alike are used to gels and are hesitant to use non-gel formulations. This project will identify a suitable gel base to formulate a hand rub containing hypochlorous acid whilst maintaining the superior efficacy of the hypochlorous acid compared to alcohol as a biocide. It will look at optimal dose rate and rub time. The end result will be a safe, broad-spectrum efficacious hand rub that possesses all the convenience attributes of an ABHR without the disadvantages. The labelling would be designed to make it clear how much should be used to comply with the requirements of BSEN 1500 and the packaging would have a simple use mechanism to dispense that volume.

许多社区和卫生保健相关的感染是可以通过良好的手部卫生来预防的，即在正确的时间和以最合适的方法清洁双手。事实上，加强手部卫生一直是政府遏制新冠肺炎大流行战略的关键部分。保持良好手部卫生的最佳方法是使用肥皂和热自来水。然而，这并不总是可能的、实用的或方便的。这导致了酒精类洗手液（ABHRs）的使用激增。ABHRs不是使用标准成分生产的，也没有标准/声明的强度，尽管最低65%的浓度是有效的。此外，这些产品很少在标签上有使用说明，尽管BSEN 1500规定6 ml（每次用3 ml洗涤2次）是必要的剂量。不同的醇具有不同的靶生物谱，并且并非所有的醇都对所有病原体有效。ABHR可能会导致手干燥/开裂，如果应用于破损的皮肤，可能会刺痛。此外，它们是易燃的，如果摄入会造成伤害。它们在所有环境中使用都不安全（例如小学，痴呆症护理机构），并且不被某些信仰的人接受。该项目的重点是创造一种基于次氯酸的方便有效的手擦。次氯酸是由哺乳动物机体对病原体攻击的反应产生的。它是一种快速、安全的杀菌剂，可有效对抗多种病原体（细菌、病毒、酵母菌、霉菌、原生动物、孢子）。它已经以液体形式（硬表面消毒和手部卫生）用于医疗保健领域，但专业用户和消费者都习惯于凝胶，并不愿意使用非凝胶制剂。该项目将确定一种合适的凝胶基质，用于配制含次氯酸的手擦，同时保持次氯酸作为杀菌剂与酒精相比的上级功效。它将着眼于最佳剂量率和摩擦时间。最终的结果将是一种安全、广谱有效的手擦，具有ABHR的所有便利属性，而没有缺点。标签的设计将明确说明应使用多少才符合BSEN 1500的要求，包装将有一个简单的使用机制来分配该体积。