MECHANISMS OF HETEROGENEITY IN THE LUNG

这项正在进行的研究的下一阶段将解决的机制， 影响肺部的异质性。 基于以前在这方面的工作， 方案，拟议方案的重点是机制， 肺通气和灌注的异质性。 的项目 分别处理通气或灌注， 二是影响气体交换和水肿形成。 该方法是多学科的，调查人员接受了以下方面的培训： 医学、生理学、麻醉学、形态学、工程学和 放射学. 这是20年来对肺疾病的关注的结果， 生理学和医学以及研究人员之间的合作。 的 该计划旨在支持其他研究，特别是在ARDS和 肺血管疾病，这是在这个机构进行。 的 该提案的优点包括融合了许多学科， 这组调查人员的生产力和扩大 使用成像的实验方法，荧光微球，组织 扩散细胞和通气异质性的气溶胶评估。 其结果应该是通过以下方式更全面地了解这些机制： 肺会对通气和灌注的扰动做出反应 健康和疾病的分布。

The next phase of this ongoing research will address the mechanisms which affect heterogeneity in the lungs. Building on previous work in this program, the focus of the proposed program is on the mechanisms of heterogeneity of ventilation and perfusion in the lungs. The projects deal either with ventilation or perfusion separately, the matching of the two as it affects gas exchange and influences on edema formation. The approach is multidisciplinary, with investigators trained in medicine, physiology, anesthesiology, morphology, engineering and radiology. It is a result of two decades of interest in pulmonary physiology and medicine and collaboration between the investigators. The program is designed to support other research, particularly in ARDS and pulmonary vascular disease, which is proceeding at this institution. The strengths of the proposal include the integration of many disciplines, the productivity of this group of investigators and the expansion of experimental approaches using imaging, fluorescent microspheres, tissue diffusion cells, and aerosol assessment of ventilation heterogeneity. The outcome should be a more complete understanding of the mechanisms by which the lungs respond to perturbations in ventilation and perfusion distribution both in health and disease.