MECHANISMS OF HETEROGENEITY IN LUNG

该计划的重点是异构性的机制 肺内的通风和灌流。该计划由五个部分组成 项目和三个核心，既涉及区域内项目，也涉及 区域间的异质性机制。这些项目要么达成协议，要么 在单独通风或灌流的情况下，两者的匹配为 它影响气体交换，并影响浮肿的形成。这个 方法是多学科的，调查人员受过医学方面的培训， 生理学、麻醉学、生物工程学、形态学、工程学、 和放射科。这是二十年来人们对 肺生理学与医学之间的合作 调查人员。该计划旨在支持其他研究， 尤其是ARDS和肺血管疾病，目前正在进行 在华盛顿大学。该计划的优势包括 多个学科的融合，这群人的生产力 研究人员，以及采用新的实验方法 图像、形态重建和分形学评价 异质性。

The focus of the program is on the mechanisms of heterogeneity of ventilation and perfusion in the lung. The program consists of five projects and three cores which address both intraregional and interregional mechanisms of heterogeneity. The projects deal either with ventilation or perfusion separately, the matching of the two as it affects gas exchange and influences on edema formation. The approach is multidisplinary, with investigators trained in medicine, physiology, anesthesiology, bioengineering, morphology, engineering, and radiology. It is the result of two decades of interest in pulmonary physiology and medicine and collaboration between the investigators. The program is designed to support other research, particular in ARDS and pulmonary vascular disease, which is proceeding at the University of Washington. The strengths of the program include the integration of many disciplines, the productivity of this group of investigators, and the adoption of new experimental approaches using imaging, morphological reconstruction, and fractal evaluation of heterogeneity.