MECHANISMS OF HETEROGENEITY IN LUNG

肺部异质性机制

• 批准号: 6308552
• 负责人: Michael Peter Hlastala
• 金额: $ 2.35万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308552
• 关键词: Mammalia; bioengineering /biomedical engineering; biomedical resource; human tissue; respiratory system; technology /technique

The focus of the program is on the mechanisms of heterogeneity of ventilation and perfusion in the lung. The program consists of five projects and three cores which address both intraregional and interregional mechanisms of heterogeneity. The projects deal either with ventilation or perfusion separately, the matching of the two as it affects gas exchange and influences on edema formation. The approach is multidisplinary, with investigators trained in medicine, physiology, anesthesiology, bioengineering, morphology, engineering, and radiology. It is the result of two decades of interest in pulmonary physiology and medicine and collaboration between the investigators. The program is designed to support other research, particular in ARDS and pulmonary vascular disease, which is proceeding at the University of Washington. The strengths of the program include the integration of many disciplines, the productivity of this group of investigators, and the adoption of new experimental approaches using imaging, morphological reconstruction, and fractal evaluation of heterogeneity.

该计划的重点是异质性机制 肺的通气和灌注。 该计划由五部分组成 项目和三个核心，涉及区域内和 区域间异质性机制。 这些项目涉及 分别采用通气或灌注，两者的匹配为 它影响气体交换并影响水肿的形成。 这 方法是多学科的，研究人员接受过医学培训， 生理学、麻醉学、生物工程、形态学、工程学、 和放射学。 这是二十年来的兴趣的结果 肺生理学和医学以及之间的合作 调查人员。 该计划旨在支持其他研究， 特别是在 ARDS 和肺血管疾病方面，该领域正在进行 在华盛顿大学。 该计划的优势包括 多学科的融合，这群人的生产力 研究人员，并采用新的实验方法 成像、形态重建和分形评估 异质性。