PREPARATION OF GONADAL CELLS AND CELL FRACTIONS

性腺细胞和细胞组分的制备

• 批准号: 2316064
• 负责人: NORMAN N BEAUDRY
• 金额: $ 34.54万
• 依托单位: COVANCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-11 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2316064
• 关键词: PREPARATION; GONADAL; CELLS; CELL; FRACTIONS

The program on analysis of gonadotropin receptors and actions of gonadotropic hormones is an important component of the Endocrinology and Reproduction Research Branch scientific research objectives. This program is supported by a Contract that provides large amounts of well characterized preparations including purified gonadal cells, various short term and established cell cultures, gonadal tissues and cell fractions, and receptor preparations. Gonadal cells are prepared acutely from a large number of control animals and under multiple protocols. The contract supports work in reproductive biology allowing investigators to perform studies on the binding characteristics of gonadotropin and prolactin receptors of testicular, ovarian, Nb2 lymphoma and several transfected cells, and cell membranes; and of the biological characterization of LH and related hormones, and studies on the mechanisms of hormone-receptor interaction, signal transduction, interaction between signalling pathways, and modulation of key metabolic steps of the androgen biosynthetic pathways.

促性腺激素受体及其作用分析程序 促性腺激素是内分泌的重要组成部分 生殖研究分会的科研目标。 这个节目 由提供大量油井的合同支持 特征制剂包括纯化的性腺细胞、各种短 术语和已建立的细胞培养物、性腺组织和细胞组分， 和受体制剂。 性腺细胞是从 大量对照动物并在多种方案下。 这 合同支持生殖生物学工作，使研究人员能够 对促性腺激素的结合特性进行研究 睾丸、卵巢、Nb2 淋巴瘤等的催乳素受体 转染细胞和细胞膜；和生物的 LH及相关激素的表征及其机制研究 激素-受体相互作用、信号转导、相互作用 信号通路和雄激素关键代谢步骤的调节 生物合成途径。