PREPARATION OF GONADAL CELLS AND CELL FRACTIONS

性腺细胞和细胞组分的制备

• 批准号: 2316064
• 负责人: NORMAN N BEAUDRY
• 金额: $ 34.54万
• 依托单位: COVANCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-11 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2316064
• 关键词: PREPARATION; GONADAL; CELLS; CELL; FRACTIONS

The program on analysis of gonadotropin receptors and actions of gonadotropic hormones is an important component of the Endocrinology and Reproduction Research Branch scientific research objectives. This program is supported by a Contract that provides large amounts of well characterized preparations including purified gonadal cells, various short term and established cell cultures, gonadal tissues and cell fractions, and receptor preparations. Gonadal cells are prepared acutely from a large number of control animals and under multiple protocols. The contract supports work in reproductive biology allowing investigators to perform studies on the binding characteristics of gonadotropin and prolactin receptors of testicular, ovarian, Nb2 lymphoma and several transfected cells, and cell membranes; and of the biological characterization of LH and related hormones, and studies on the mechanisms of hormone-receptor interaction, signal transduction, interaction between signalling pathways, and modulation of key metabolic steps of the androgen biosynthetic pathways.

促性腺激素受体及其作用分析程序 促性腺激素是内分泌学的重要组成部分， 生殖研究分支科学研究目标。 这个程序 有一份合同支持，该合同提供大量的油井， 特征性制剂包括纯化的性腺细胞、各种短 长期和建立的细胞培养物，性腺组织和细胞组分， 和受体制剂。 性腺细胞是从一种 大量的对照动物和多种方案。 的 合同支持生殖生物学的工作，允许研究人员 研究促性腺激素的结合特性， 睾丸、卵巢、Nb 2淋巴瘤和几种 转染的细胞和细胞膜;以及生物 LH和相关激素的表征，以及机制的研究 受体相互作用，信号转导， 信号通路和调节雄激素的关键代谢步骤 生物合成途径